Source:http://linkedlifedata.com/resource/pubmed/id/10386929
Bioorg. Med. Chem. Lett. 1999 Jun 7 9 11 1527-32
General Info
Affiliation
The Department of Medicinal Chemistry, The University of Kansas, Lawrence 66045, USA.Abstract
We have developed a novel strategy for the preparation of tetrahedral transition state analogs for aspartic acid and metallo-proteases based upon the sulfonimidamide functional group. Our best alpha-des-amino dipeptide analog binds at least 100-fold tighter than the corresponding ground state structure (i.e., amide). A previously unpublished five-membered cyclic sulfonimidamide was also synthesized.
PMID
10386929