Source:http://linkedlifedata.com/resource/pubmed/id/10386928
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
11
|
| pubmed:dateCreated |
1999-9-23
|
| pubmed:abstractText |
The novel triterpene 1 with a dammarane skeleton and a hitherto unknown 17alpha-substitution pattern has been isolated from the Palmyrah palm in low yield and prepared by synthesis in larger quantities. 1 was shown to be an extremely potent immunosuppressant in vitro (MLR; IC50 = 10 ng/ml) and in vivo (DTH; ED50 = 0.01 mg/kg p.o.). A glucocorticoid like activity is excluded.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jun
|
| pubmed:issn |
0960-894X
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
7
|
| pubmed:volume |
9
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1521-6
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:10386928-Humans,
pubmed-meshheading:10386928-Immunosuppressive Agents,
pubmed-meshheading:10386928-Inhibitory Concentration 50,
pubmed-meshheading:10386928-Jurkat Cells,
pubmed-meshheading:10386928-Lymphocytes,
pubmed-meshheading:10386928-Models, Chemical,
pubmed-meshheading:10386928-Plant Proteins,
pubmed-meshheading:10386928-Triterpenes,
pubmed-meshheading:10386928-Tumor Cells, Cultured
|
| pubmed:year |
1999
|
| pubmed:articleTitle |
Isolation and synthesis of a novel immunosuppressive 17alpha-substituted dammarane from the flour of the Palmyrah palm (Borassus flabellifer).
|
| pubmed:affiliation |
Novartis Pharma AG, Arthritis and Bone Research, Switzerland. laszlo.revesz@pharma.novartis.com
|
| pubmed:publicationType |
Journal Article
|