Linked Life Data

10382885

Source:http://linkedlifedata.com/resource/pubmed/id/10382885

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1999-9-16
pubmed:abstractText
An agar dilution MIC method was used to test the activity of gatifloxacin, a new broad-spectrum fluoroquinolone, compared with ciprofloxacin, levofloxacin, sparfloxacin, trovafloxacin, amoxycillin, cefuroxime, ceftriaxone and clarithromycin against 71 penicillin-susceptible, 81 penicillin-intermediate and 55 penicillin-resistant pneumococci. Quinolone activity was unaffected by penicillin susceptibility, with MIC50/MIC90s (mg/L) of 0.25/0.5 for gatifloxacin; 1/2 for ciprofloxacin; 1/2 for levofloxacin; 0.25/0.5 for sparfloxacin; 0.125/0.25 for trovafloxacin. beta-Lactam and clarithromycin MICs rose with those of penicillin G; MIC50/MIC90 values (mg/L) for penicillin-susceptible, -intermediate and -resistant strains were: 0.03/0.06, 0.25/1, 2/4 for penicillin G; 0.03/0.03, 0.125/1, 2/4 for amoxycillin; 0.03/0.125, 0.5/4, 8/16 for cefuroxime; 0.03/0.03, 0.25/0.5, 2/4 for ceftriaxone; 0.03/0.06, 0.03/>64, 1/>64 for clarithromycin. Time-kill testing of four penicillin-susceptible, four -intermediate and four -resistant strains showed that levofloxacin at the MIC, gatifloxacin and sparfloxacin at 2 x MIC, and trovafloxacin and ciprofloxacin at 4 x MIC, were bactericidal (99.9% killing) for all strains after 12 h and 24 h. By contrast, amoxycillin, cefuroxime and ceftriaxone showed bactericidal activity after 24 h against all strains at 4, 8 and 4 x MIC, respectively. Against ten organisms with clarithromycin MICs of 0.03-4.0 mg/L, clarithromycin was bactericidal against seven strains at 8 x MIC after 24 h. Quinolones showed more rapid killing at lower concentrations and earlier time periods than did beta-lactams and clarithromycin.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Amoxicillin, http://linkedlifedata.com/resource/pubmed/chemical/Anti-Infective Agents, http://linkedlifedata.com/resource/pubmed/chemical/Ceftriaxone, http://linkedlifedata.com/resource/pubmed/chemical/Cefuroxime, http://linkedlifedata.com/resource/pubmed/chemical/Cephalosporins, http://linkedlifedata.com/resource/pubmed/chemical/Ciprofloxacin, http://linkedlifedata.com/resource/pubmed/chemical/Clarithromycin, http://linkedlifedata.com/resource/pubmed/chemical/Fluoroquinolones, http://linkedlifedata.com/resource/pubmed/chemical/Naphthyridines, http://linkedlifedata.com/resource/pubmed/chemical/Ofloxacin, http://linkedlifedata.com/resource/pubmed/chemical/gatifloxacin, http://linkedlifedata.com/resource/pubmed/chemical/sparfloxacin, http://linkedlifedata.com/resource/pubmed/chemical/trovafloxacin
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0305-7453
pubmed:author
pubmed:issnType
Print
pubmed:volume
43
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
645-9
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1999
pubmed:articleTitle
Anti-pneumococcal activity of gatifloxacin compared with other quinolone and non-quinolone agents.
pubmed:affiliation
Department of Pathology, Hershey Medical Center, PA 17033, USA.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't