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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
1999-8-3
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pubmed:abstractText |
Previous studies show that inflammatory cytokines play a part in the development of insulin resistance. Thiazolidinediones were developed as insulin-sensitizing drugs and are ligands for the peroxisome proliferator-activated receptory (PPARgamma). We hypothesized that the anti-diabetic mechanism of thiazolidinediones depends on the quantity of PPARgamma in the insulin resistant state in which inflammatory cytokines play a part.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/2,4-thiazolidinedione,
http://linkedlifedata.com/resource/pubmed/chemical/Cytokines,
http://linkedlifedata.com/resource/pubmed/chemical/Deoxyglucose,
http://linkedlifedata.com/resource/pubmed/chemical/Glucose Transporter Type 4,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin,
http://linkedlifedata.com/resource/pubmed/chemical/Monosaccharide Transport Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Muscle Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cytoplasmic and Nuclear,
http://linkedlifedata.com/resource/pubmed/chemical/Slc2a4 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Thiazoles,
http://linkedlifedata.com/resource/pubmed/chemical/Thiazolidinediones,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0012-186X
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pubmed:author |
pubmed-author:ChunT HTH,
pubmed-author:DoiKK,
pubmed-author:FukunagaYY,
pubmed-author:HosodaKK,
pubmed-author:InoueGG,
pubmed-author:InoueMM,
pubmed-author:ItohHH,
pubmed-author:MasatsuguKK,
pubmed-author:NakaiMM,
pubmed-author:NishimuraHH,
pubmed-author:SaitoTT,
pubmed-author:SawadaNN,
pubmed-author:ShintaniMM,
pubmed-author:TanakaTT,
pubmed-author:YamashitaJJ,
pubmed-author:YoshimasaYY
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pubmed:issnType |
Print
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pubmed:volume |
42
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
702-10
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:10382590-Adipocytes,
pubmed-meshheading:10382590-Amino Acid Sequence,
pubmed-meshheading:10382590-Animals,
pubmed-meshheading:10382590-Base Sequence,
pubmed-meshheading:10382590-Cells, Cultured,
pubmed-meshheading:10382590-Cloning, Molecular,
pubmed-meshheading:10382590-Cytokines,
pubmed-meshheading:10382590-Deoxyglucose,
pubmed-meshheading:10382590-Down-Regulation,
pubmed-meshheading:10382590-Glucose Transporter Type 4,
pubmed-meshheading:10382590-Insulin,
pubmed-meshheading:10382590-Male,
pubmed-meshheading:10382590-Molecular Sequence Data,
pubmed-meshheading:10382590-Monosaccharide Transport Proteins,
pubmed-meshheading:10382590-Muscle Proteins,
pubmed-meshheading:10382590-RNA, Messenger,
pubmed-meshheading:10382590-Rats,
pubmed-meshheading:10382590-Rats, Sprague-Dawley,
pubmed-meshheading:10382590-Receptors, Cytoplasmic and Nuclear,
pubmed-meshheading:10382590-Thiazoles,
pubmed-meshheading:10382590-Thiazolidinediones,
pubmed-meshheading:10382590-Transcription Factors,
pubmed-meshheading:10382590-Tumor Necrosis Factor-alpha
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pubmed:year |
1999
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pubmed:articleTitle |
Down regulation of peroxisome proliferator-activated receptorgamma expression by inflammatory cytokines and its reversal by thiazolidinediones.
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pubmed:affiliation |
Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Sakyouku, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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