Linked Life Data

10382580

Source:http://linkedlifedata.com/resource/pubmed/id/10382580

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1999-7-15
pubmed:abstractText
The objective of this study was to evaluate the effect of recombinant human bone morphogenetic protein-2 (rhBMP-2) concentration on regeneration of alveolar bone and cementum, and on associated root resorption and ankylosis. Contralateral, critical size, supra-alveolar, periodontal defects were surgically produced and immediately implanted with rhBMP-2 in an absorbable collagen sponge (ACS) carrier in 8, young adult, male, beagle dogs. 6 animals received rhBMP-2/ACS (rhBMP-2 at 0.05, 0.10, or 0.20 mg/mL; total construct volume/defect approximately 4.0 mL) in contralateral defects following an incomplete block design. 2 animals received rhBMP-2/ACS (rhBMP-2 at 0 and 0.10 mg/mL) in contralateral defects (controls). The animals were euthanised at 8 weeks post-surgery and block sections of the defects were collected for histologic and histometric analysis. Supra-alveolar periodontal defects receiving rhBMP-2 at 0.05, 0.10, or 0.20 mg/ml exhibited extensive alveolar regeneration comprising 86%, 96%, and 88% of the defect height, respectively. Cementum regeneration encompassed 8%, 6%, and 8% of the defect height, respectively. Root resorption was observed for all rhBMP-2 concentrations. Ankylosis was observed in almost all teeth receiving rhBMP-2. Control defects without rhBMP-2 exhibited limited, if any, evidence of alveolar bone and cementum regeneration, root resorption, or ankylosis. Within the selected rhBMP-2 concentration and observation interval, there appear to be no meaningful differences in regeneration of alveolar bone and cementum. There also appear to be no significant differences in the incidence and extent of root resorption and ankylosis, though there may be a positive correlation with rhBMP-2 concentration.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
D
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0303-6979
pubmed:author
pubmed:issnType
Print
pubmed:volume
26
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
392-400
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed-meshheading:10382580-Absorbable Implants, pubmed-meshheading:10382580-Alveolar Bone Loss, pubmed-meshheading:10382580-Animals, pubmed-meshheading:10382580-Bone Morphogenetic Protein 2, pubmed-meshheading:10382580-Bone Morphogenetic Proteins, pubmed-meshheading:10382580-Bone Regeneration, pubmed-meshheading:10382580-Cattle, pubmed-meshheading:10382580-Collagen, pubmed-meshheading:10382580-Dental Cementum, pubmed-meshheading:10382580-Dental Implantation, Endosseous, pubmed-meshheading:10382580-Dental Implants, pubmed-meshheading:10382580-Dogs, pubmed-meshheading:10382580-Humans, pubmed-meshheading:10382580-Implants, Experimental, pubmed-meshheading:10382580-Male, pubmed-meshheading:10382580-Mandible, pubmed-meshheading:10382580-Periodontal Attachment Loss, pubmed-meshheading:10382580-Recombinant Proteins, pubmed-meshheading:10382580-Regeneration, pubmed-meshheading:10382580-Root Resorption, pubmed-meshheading:10382580-Tooth Ankylosis, pubmed-meshheading:10382580-Transforming Growth Factor beta
pubmed:year
1999
pubmed:articleTitle
Periodontal repair in dogs: effect of rhBMP-2 concentration on regeneration of alveolar bone and periodontal attachment.
pubmed:affiliation
Bone Biology and Applications, Genetics Institute, Inc., Andover, MA, USA. uwikesjo@dental.temple.edu
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't