|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
7
|
|
pubmed:dateCreated |
1999-8-9
|
|
pubmed:abstractText |
5-Bromodeoxyuridine is a radiosensitizing agent that is currently being evaluated in clinical trials as an adjuvant in the treatment of a variety of cancers. gamma-Radiolysis and UV irradiation of oligonucleotides containing 5-bromodeoxyuridine result in the formation of direct strand breaks at the 5'-adjacent nucleotide by oxidation of the respective deoxyribose. We investigated the effects of DNA secondary structure and O2 on the induction of direct strand breaks in 5-bromodeoxyuridine-containing oligonucleotides.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jul
|
|
pubmed:issn |
1074-5521
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
6
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
451-9
|
|
pubmed:dateRevised |
2007-11-14
|
|
pubmed:meshHeading |
pubmed-meshheading:10381405-Bromodeoxyuridine,
pubmed-meshheading:10381405-DNA,
pubmed-meshheading:10381405-Deuterium,
pubmed-meshheading:10381405-Kinetics,
pubmed-meshheading:10381405-Models, Chemical,
pubmed-meshheading:10381405-Nucleic Acid Conformation,
pubmed-meshheading:10381405-Oligonucleotides,
pubmed-meshheading:10381405-Oxygen,
pubmed-meshheading:10381405-Spectrometry, Mass, Matrix-Assisted Laser...,
pubmed-meshheading:10381405-Ultraviolet Rays
|
|
pubmed:year |
1999
|
|
pubmed:articleTitle |
The effects of secondary structure and O2 on the formation of direct strand breaks upon UV irradiation of 5-bromodeoxyuridine-containing oligonucleotides.
|
|
pubmed:affiliation |
Department of Chemistry, Colorado State University, Fort Collins, CO 80523, USA.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
|
