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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
1999-8-9
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pubmed:abstractText |
Mitomycin C (MC), a DNA cross-linking and alkylating agent, targets guanines in the m5CpG sequence with 2-3-fold preference over guanines in unmethylated CpG. Benzo[a]pyrenediolepoxide (BPDE) and several other aromatic carcinogens form guanine adducts with an identical selectivity for m5CpG, and in certain cancers G to T transversion mutation 'hotspots' in the p53 tumor suppressor gene are more frequent at this sequence than at guanines in other sequences. MC appears suitable to probe the general mechanism of this selectivity.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1074-5521
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
6
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
461-71
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:10381403-7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide,
pubmed-meshheading:10381403-Alkylation,
pubmed-meshheading:10381403-Cross-Linking Reagents,
pubmed-meshheading:10381403-DNA,
pubmed-meshheading:10381403-DNA Fragmentation,
pubmed-meshheading:10381403-Guanine,
pubmed-meshheading:10381403-Magnetic Resonance Spectroscopy,
pubmed-meshheading:10381403-Mitomycin,
pubmed-meshheading:10381403-Mutation,
pubmed-meshheading:10381403-Nucleic Acid Conformation
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pubmed:year |
1999
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pubmed:articleTitle |
Reactivity of guanine at m5CpG steps in DNA: evidence for electronic effects transmitted through the base pairs.
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pubmed:affiliation |
Department of Chemistry, Hunter College, CUNY, New York, NY 10021, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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