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rdf:type |
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lifeskim:mentions |
umls-concept:C0006556,
umls-concept:C0007634,
umls-concept:C0020792,
umls-concept:C0035687,
umls-concept:C0043393,
umls-concept:C0072262,
umls-concept:C0086418,
umls-concept:C0162638,
umls-concept:C0205263,
umls-concept:C0205314,
umls-concept:C0679622,
umls-concept:C0851285,
umls-concept:C0949597,
umls-concept:C1334043,
umls-concept:C1521761,
umls-concept:C1568080
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pubmed:issue |
1
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pubmed:dateCreated |
1999-7-29
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pubmed:abstractText |
We have examined specific genes whose expression is altered during apoptosis induced by prostaglandin (PG)A2 and Delta12-PGJ2 in human hepatocellular carcinoma Hep3B cells. Using mRNA differential display, we have identified two genes: one is specifically up-regulated and encodes for human Sox-4 (Sry-HMG box gene) and the other is significantly down-regulated and is the human homolog of yeast Ssf-1, a novel splicing factor. Northern blot analysis confirmed their differential expressions. Interestingly, Sox-4 was highly expressed in subcutaneous tumors grown in nude mice as a xenograft from Hep3B cells. These results suggest that the expression of Sox-4 may be related to the apoptosis pathway leading to cell death as well as to tumorigenesis, and that Ssf-1 gene may serve as a negative regulator of PGA2/Delta12-PGJ2-mediated Hep3B cell apoptosis.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Complementary,
http://linkedlifedata.com/resource/pubmed/chemical/High Mobility Group Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/PPAN protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Prostaglandins A,
http://linkedlifedata.com/resource/pubmed/chemical/SOX4 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/SOXC Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/SSF1 protein, S cerevisiae,
http://linkedlifedata.com/resource/pubmed/chemical/Saccharomyces cerevisiae Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Sox4 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators,
http://linkedlifedata.com/resource/pubmed/chemical/prostaglandin A2
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0006-291X
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 1999 Academic Press.
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pubmed:issnType |
Print
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pubmed:day |
24
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pubmed:volume |
260
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
216-21
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:10381369-Animals,
pubmed-meshheading:10381369-Apoptosis,
pubmed-meshheading:10381369-Base Sequence,
pubmed-meshheading:10381369-DNA, Complementary,
pubmed-meshheading:10381369-Down-Regulation,
pubmed-meshheading:10381369-High Mobility Group Proteins,
pubmed-meshheading:10381369-Humans,
pubmed-meshheading:10381369-Mice,
pubmed-meshheading:10381369-Mice, Inbred BALB C,
pubmed-meshheading:10381369-Molecular Sequence Data,
pubmed-meshheading:10381369-Nuclear Proteins,
pubmed-meshheading:10381369-Prostaglandins A,
pubmed-meshheading:10381369-SOXC Transcription Factors,
pubmed-meshheading:10381369-Saccharomyces cerevisiae Proteins,
pubmed-meshheading:10381369-Time Factors,
pubmed-meshheading:10381369-Trans-Activators,
pubmed-meshheading:10381369-Tumor Cells, Cultured,
pubmed-meshheading:10381369-Up-Regulation
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pubmed:year |
1999
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pubmed:articleTitle |
Identification of cDNAs for Sox-4, an HMG-Box protein, and a novel human homolog of yeast splicing factor SSF-1 differentially regulated during apoptosis induced by prostaglandin A2/delta12-PGJ2 in Hep3B cells.
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pubmed:affiliation |
Department of Biochemistry, Research Institute of Molecular Genetics, College of Medicine, Catholic University of Korea, 505 Banpo-Dong, Socho-Gu, Seoul, 137-701, Korea.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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