Source:http://linkedlifedata.com/resource/pubmed/id/10380928
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
6
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pubmed:dateCreated |
1999-7-22
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pubmed:abstractText |
D-type cyclins and cyclin E represent two very distinct classes of mammalian G1 cyclins. We have generated a mouse strain in which the coding sequences of the cyclin D1 gene (Ccnd1) have been deleted and replaced by those of human cyclin E (CCNE). In the tissues and cells of these mice, the expression pattern of human cyclin E faithfully reproduces that normally associated with mouse cyclin D1. The replacement of cyclin D1 with cyclin E rescues all phenotypic manifestations of cyclin D1 deficiency and restores normal development in cyclin D1-dependent tissues. Thus, cyclin E can functionally replace cyclin D1. Our analyses suggest that cyclin E is the major downstream target of cyclin D1.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0092-8674
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
11
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pubmed:volume |
97
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
767-77
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:10380928-Animals,
pubmed-meshheading:10380928-Cyclin D1,
pubmed-meshheading:10380928-Cyclin E,
pubmed-meshheading:10380928-Humans,
pubmed-meshheading:10380928-Mice,
pubmed-meshheading:10380928-Mice, Inbred C57BL,
pubmed-meshheading:10380928-Phenotype,
pubmed-meshheading:10380928-Receptors, Estrogen,
pubmed-meshheading:10380928-Retina
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pubmed:year |
1999
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pubmed:articleTitle |
Rescue of cyclin D1 deficiency by knockin cyclin E.
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pubmed:affiliation |
Dana-Farber Cancer Institute, and Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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