|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
6
|
|
pubmed:dateCreated |
1999-7-22
|
|
pubmed:databankReference |
|
|
pubmed:abstractText |
During C. elegans development, Wnt/WG signaling is required for differences in cell fate between sister cells born from anterior/posterior divisions. A beta-catenin-related gene, wrm-1, and the lit-1 gene are effectors of this signaling pathway and appear to downregulate the activity of POP-1, a TCF/LEF-related protein, in posterior daughter cells. We show here that lit-1 encodes a serine/threonine protein kinase homolog related to the Drosophila tissue polarity protein Nemo. We demonstrate that the WRM-1 protein binds to LIT-1 in vivo and that WRM-1 can activate the LIT-1 protein kinase when coexpressed in vertebrate tissue culture cells. This activation leads to phosphorylation of POP-1 and to apparent changes in its subcellular localization. Our findings provide evidence for novel regulatory avenues for an evolutionarily conserved Wnt/WG signaling pathway.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Caenorhabditis elegans Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Cytoskeletal Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Helminth Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/High Mobility Group Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Mom-5 protein, C elegans,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Serine-Threonine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators,
http://linkedlifedata.com/resource/pubmed/chemical/beta Catenin,
http://linkedlifedata.com/resource/pubmed/chemical/pop-1 protein, C elegans
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jun
|
|
pubmed:issn |
0092-8674
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
11
|
|
pubmed:volume |
97
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
717-26
|
|
pubmed:dateRevised |
2009-11-19
|
|
pubmed:meshHeading |
pubmed-meshheading:10380924-Amino Acid Sequence,
pubmed-meshheading:10380924-Animals,
pubmed-meshheading:10380924-COS Cells,
pubmed-meshheading:10380924-Caenorhabditis elegans,
pubmed-meshheading:10380924-Caenorhabditis elegans Proteins,
pubmed-meshheading:10380924-Cytoskeletal Proteins,
pubmed-meshheading:10380924-DNA-Binding Proteins,
pubmed-meshheading:10380924-Enzyme Activation,
pubmed-meshheading:10380924-Helminth Proteins,
pubmed-meshheading:10380924-High Mobility Group Proteins,
pubmed-meshheading:10380924-Membrane Proteins,
pubmed-meshheading:10380924-Mitogen-Activated Protein Kinases,
pubmed-meshheading:10380924-Molecular Sequence Data,
pubmed-meshheading:10380924-Phosphorylation,
pubmed-meshheading:10380924-Protein-Serine-Threonine Kinases,
pubmed-meshheading:10380924-Signal Transduction,
pubmed-meshheading:10380924-Trans-Activators,
pubmed-meshheading:10380924-beta Catenin
|
|
pubmed:year |
1999
|
|
pubmed:articleTitle |
WRM-1 activates the LIT-1 protein kinase to transduce anterior/posterior polarity signals in C. elegans.
|
|
pubmed:affiliation |
University of Massachusetts Medical School, Program in Molecular Medicine, Worcester 01605, USA.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|
