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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1999-9-1
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pubmed:abstractText |
The binding of [125I]p-iodoclonidine to alpha-2, and/or [125I]iodopindolol to beta-1 and beta-2 adrenoceptors was measured in right prefrontal cortex (Brodmann's area 10) and right hippocampus from subjects with DSM-III-R diagnoses of major depression (n = 15) or schizophrenia (n = 8) as well as from control subjects (n = 20). No significant differences between study groups were observed in binding to alpha-2 adrenoceptors in any of the six layers of prefrontal cortex or in any of the hippocampal fields. Likewise, there were no significant differences in beta-1 or beta-2 adrenoceptor binding in any of the hippocampal fields between control and major depressive subjects. In contrast, binding to beta-1 adrenoceptors, but not beta-2 adrenoceptors, was significantly lower (-13 to -27%) in most hippocampal fields of schizophrenic subjects as compared to control subjects or to major depressives. Alterations in beta-1 adrenoceptor binding in the hippocampus of schizophrenics provide further evidence for a role of central noradrenergic neurons in the neurochemical pathology of schizophrenia.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/3-iodopindolol,
http://linkedlifedata.com/resource/pubmed/chemical/4-iodoclonidine,
http://linkedlifedata.com/resource/pubmed/chemical/Adrenergic alpha-Agonists,
http://linkedlifedata.com/resource/pubmed/chemical/Adrenergic beta-Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Affinity Labels,
http://linkedlifedata.com/resource/pubmed/chemical/Clonidine,
http://linkedlifedata.com/resource/pubmed/chemical/Iodine Radioisotopes,
http://linkedlifedata.com/resource/pubmed/chemical/Norepinephrine,
http://linkedlifedata.com/resource/pubmed/chemical/Pindolol,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Adrenergic
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0893-133X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
21
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
69-81
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pubmed:dateRevised |
2011-5-18
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pubmed:meshHeading |
pubmed-meshheading:10379521-Adrenergic alpha-Agonists,
pubmed-meshheading:10379521-Adrenergic beta-Antagonists,
pubmed-meshheading:10379521-Adult,
pubmed-meshheading:10379521-Affinity Labels,
pubmed-meshheading:10379521-Aged,
pubmed-meshheading:10379521-Autoradiography,
pubmed-meshheading:10379521-Brain Chemistry,
pubmed-meshheading:10379521-Clonidine,
pubmed-meshheading:10379521-Depressive Disorder,
pubmed-meshheading:10379521-Female,
pubmed-meshheading:10379521-Hippocampus,
pubmed-meshheading:10379521-Humans,
pubmed-meshheading:10379521-Iodine Radioisotopes,
pubmed-meshheading:10379521-Male,
pubmed-meshheading:10379521-Middle Aged,
pubmed-meshheading:10379521-Norepinephrine,
pubmed-meshheading:10379521-Pindolol,
pubmed-meshheading:10379521-Prefrontal Cortex,
pubmed-meshheading:10379521-Receptors, Adrenergic,
pubmed-meshheading:10379521-Schizophrenia,
pubmed-meshheading:10379521-Suicide
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pubmed:year |
1999
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pubmed:articleTitle |
Brain noradrenergic receptors in major depression and schizophrenia.
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pubmed:affiliation |
Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson 39216-4505, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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