Linked Life Data

10377976

Source:http://linkedlifedata.com/resource/pubmed/id/10377976

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1999-7-16
pubmed:abstractText
Mutant mice with retinal degeneration (rd/rd) were given 1-h pulses of light of varying brightness at times of the night when they would normally be active. The mutant mice showed a significantly greater inhibition of locomotor activity to light (negative masking) than wildtype controls. Lack of impairment, or even enhancement of negative masking suggests that this response may depend on sparing in retinally degenerate mice of the same receptor type that mediates clock resetting, because synchronization of the circadian system is known to be unimpaired in these mutants. With very dim light pulses, mutants did not change their activity, but wildtypes actually became more active (positive masking). Positive and negative masking appear to depend on different sensory and central processes.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0340-7594
pubmed:author
pubmed:issnType
Print
pubmed:volume
184
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
423-8
pubmed:dateRevised
2009-6-4
pubmed:meshHeading
pubmed:year
1999
pubmed:articleTitle
Thresholds for masking responses to light in three strains of retinally degenerate mice.
pubmed:affiliation
Department of Zoology, University of Toronto, Ontario, Canada. mro@zoo.utoronto.ca
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't