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rdf:type |
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lifeskim:mentions |
umls-concept:C0025914,
umls-concept:C0026809,
umls-concept:C0039194,
umls-concept:C0226890,
umls-concept:C0439097,
umls-concept:C0441655,
umls-concept:C0851827,
umls-concept:C1547348,
umls-concept:C1552644,
umls-concept:C1701901,
umls-concept:C1705241,
umls-concept:C1823153,
umls-concept:C2349976
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pubmed:issue |
13
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pubmed:dateCreated |
1999-7-19
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pubmed:abstractText |
We analyzed the cytolytic activity of intraepithelial T cells (IEL) isolated from the small intestines of 2- to 3-month-old mutant mice rendered deficient in different gene(s) in which the number of IEL expressing either T cell receptor (TCR)-alpha beta (alpha beta-IEL) or TCR-gamma delta (gamma delta-IEL) were absent or markedly diminished. When compared with wild-type littermates, cytolytic activity of gamma delta-IEL was sharply attenuated in TCR-beta mutant mice but remained unaltered in TCR-alpha mutant mice in which a minor population of dull TCR-beta+ (betadim)-IEL was also present. Cytolytic activity of gamma delta-IEL was maintained in mice doubly homozygous for beta2-microglobulin and transporter associated with antigen processing 1 gene mutations in which a conspicuous decrease was noted in absolute numbers of alpha beta-IEL. In contrast, both TCR-delta and IL-7 receptor-alpha gene mutations that lead to lack of gamma delta-IEL generation did not affect the development or cytolytic activity of the remaining alpha beta-IEL. The anti-CD3 and anti-TCR-gamma delta mAb-induced IFN-gamma production of gamma delta-IEL showed the same TCR-alpha and TCR-beta mutation-dependent variability. These results indicate that cytolytic and IFN-gamma-producing activities of gamma delta T cells in mouse intestinal epithelium are TCR-beta-chain-dependent.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/10377435-1359428,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10377435-1380032,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10377435-1473153,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10377435-1476600,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10377435-1535367,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10377435-1604321,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10377435-1786079,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10377435-1824857,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10377435-1986381,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10377435-2033373,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10377435-2139497,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10377435-2208290,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10377435-2384662,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10377435-2564701,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10377435-7500038,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10377435-7597094,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10377435-7947457,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10377435-7991563,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10377435-8051406,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10377435-8118887,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10377435-8208291,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10377435-8367483,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10377435-8378333,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10377435-8381716,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10377435-8609387,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10377435-8642289,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10377435-8666951,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10377435-8692964,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10377435-8760824,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10377435-8766567,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10377435-8808681,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10377435-8876213,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10377435-8879216,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10377435-8921416,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10377435-8976198,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10377435-9121121,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10377435-9159410,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10377435-9178680,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10377435-9535655
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
22
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pubmed:volume |
96
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
7451-5
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:10377435-Animals,
pubmed-meshheading:10377435-Gene Expression Regulation,
pubmed-meshheading:10377435-Immunity, Mucosal,
pubmed-meshheading:10377435-Interferon-gamma,
pubmed-meshheading:10377435-Intestinal Mucosa,
pubmed-meshheading:10377435-Mice,
pubmed-meshheading:10377435-Mutation,
pubmed-meshheading:10377435-Receptors, Antigen, T-Cell, alpha-beta,
pubmed-meshheading:10377435-Receptors, Antigen, T-Cell, gamma-delta,
pubmed-meshheading:10377435-T-Lymphocytes
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pubmed:year |
1999
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pubmed:articleTitle |
Cytolytic and IFN-gamma-producing activities of gamma delta T cells in the mouse intestinal epithelium are T cell receptor-beta-chain dependent.
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pubmed:affiliation |
Department of Microbiology, Keio University School of Medicine, Tokyo 160-8582, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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