Linked Life Data

10375863

Source:http://linkedlifedata.com/resource/pubmed/id/10375863

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1999-7-20
pubmed:abstractText
In mouse embryo development, nodal is expressed in the node during the gastrulation. It is involved in mesoderm formation and left-right axis determination. The expression of the nodal gene has a restricted spatial and temporal specificity. Studies on the function of the nodal first intron in the gene expression regulation have shown that a 220 bp fragment at the 5' end of the first intron has an enhancer activity. Rather unexpectedly, the transient transfection assays in F9 cells indicate that this fragment also displayed a promoter activity when it is cloned upstream of basic luciferase reporter gene only in sense orientation. We present here the nucleotide sequence of this 220 bp fragment, and discuss its possible role in the nodal gene regulation.
pubmed:language
chi
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0379-4172
pubmed:author
pubmed:issnType
Print
pubmed:volume
26
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
142-9
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1999
pubmed:articleTitle
[Delineation of the cis-regulatory sequences of the nodal gene].
pubmed:affiliation
College of Life Sciences, Department of Cell Biology and Genetics, Peking University, Beijing. xzhou@gwdg.de
pubmed:publicationType
Journal Article, English Abstract, Research Support, Non-U.S. Gov't