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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1999-8-5
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pubmed:abstractText |
A malignant insulinoma (LOHG-I), a carcinoid of the lung (LOHG-L), a parathyroid adenoma (LOHG-NSA), and a fibroma (LOHG-F) were obtained from a patient with multiple endocrine neoplasia type 1 (MEN1). Long-term cultures were established. Essential neurobiological properties of the cell lines were proven immunocytochemically and by electron microscopy. Molecular analysis of the germline DNA showed a 4 bp deletion in exon 3 of the MEN1 gene. Cytogenetic and CGH analyses of the tumors/tumor cell lines revealed diploidy and balanced and unbalanced structural aberrations different for each tumor. Chromosomes 6q21, 11q and 17q were most frequently involved in clonal structural aberrations.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1019-6439
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
15
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
41-51
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:10375592-Adenoma,
pubmed-meshheading:10375592-Adrenal Gland Neoplasms,
pubmed-meshheading:10375592-Adult,
pubmed-meshheading:10375592-Aneuploidy,
pubmed-meshheading:10375592-Carcinoid Tumor,
pubmed-meshheading:10375592-Chromosome Aberrations,
pubmed-meshheading:10375592-Chromosomes, Human, Pair 11,
pubmed-meshheading:10375592-DNA, Neoplasm,
pubmed-meshheading:10375592-DNA Mutational Analysis,
pubmed-meshheading:10375592-Esophageal Neoplasms,
pubmed-meshheading:10375592-Fibroma,
pubmed-meshheading:10375592-Genes, Tumor Suppressor,
pubmed-meshheading:10375592-Humans,
pubmed-meshheading:10375592-Insulinoma,
pubmed-meshheading:10375592-Leiomyoma,
pubmed-meshheading:10375592-Lung Neoplasms,
pubmed-meshheading:10375592-Male,
pubmed-meshheading:10375592-Multiple Endocrine Neoplasia Type 1,
pubmed-meshheading:10375592-Neoplasm Proteins,
pubmed-meshheading:10375592-Nucleic Acid Hybridization,
pubmed-meshheading:10375592-Pancreatic Neoplasms,
pubmed-meshheading:10375592-Parathyroid Neoplasms,
pubmed-meshheading:10375592-Pheochromocytoma,
pubmed-meshheading:10375592-Proto-Oncogene Proteins,
pubmed-meshheading:10375592-Sequence Deletion,
pubmed-meshheading:10375592-Skin Neoplasms,
pubmed-meshheading:10375592-Tumor Cells, Cultured
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pubmed:year |
1999
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pubmed:articleTitle |
Cytogenetic and CGH studies of four neuroendocrine tumors and tumor-derived cell lines of a patient with multiple endocrine neoplasia type 1.
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pubmed:affiliation |
Department of General and Experimental Pathology, University of Graz, Graz, Austria.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Case Reports
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