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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1999-8-20
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pubmed:abstractText |
Antigen-receptor signaling requires Src-family kinases to initiate tyrosine phosphorylation. CD45 dephosphorylates the inhibitory site in Src-family kinases before antigen-receptor engagement and thus serves to 'prime' the kinases. It has been unclear why CD45 does not also dephosphorylate 'activated' kinases or motifs within the cytoplasmic domains of antigen-receptors and thus prevent signal transduction. Recent reports raise the possibility that CD45 is excluded from engaged antigen-receptors by mechanisms that may include the formation of lipid microdomains.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0952-7915
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
11
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
270-6
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:10375547-Animals,
pubmed-meshheading:10375547-Antigens, CD45,
pubmed-meshheading:10375547-Cell Adhesion,
pubmed-meshheading:10375547-Humans,
pubmed-meshheading:10375547-Lymphocyte Activation,
pubmed-meshheading:10375547-Membrane Lipids,
pubmed-meshheading:10375547-Models, Biological,
pubmed-meshheading:10375547-Protein Tyrosine Phosphatases,
pubmed-meshheading:10375547-Receptors, Antigen, T-Cell,
pubmed-meshheading:10375547-Signal Transduction,
pubmed-meshheading:10375547-T-Lymphocytes,
pubmed-meshheading:10375547-src-Family Kinases
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pubmed:year |
1999
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pubmed:articleTitle |
The regulation of antigen-receptor signaling by protein tyrosine phosphatases: a hole in the story.
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pubmed:affiliation |
Howard Hughes Medical Institute, Box 8118, Departments of Pathology andMolecular Microbiology, Washington University School of Medicine, St Louis, MO 63110, USA. mthomas@pathbox.wustl.edu
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pubmed:publicationType |
Journal Article,
Review,
Research Support, Non-U.S. Gov't
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