10373320

Source:http://linkedlifedata.com/resource/pubmed/id/10373320

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0011860, umls-concept:C0012737, umls-concept:C0026336, umls-concept:C0034693, umls-concept:C0034721, umls-concept:C0314603, umls-concept:C0597336, umls-concept:C0936012
pubmed:issue	3
pubmed:dateCreated	1999-7-23
pubmed:abstractText	To identify genetic determinants relevant to non-insulin-dependent diabetes mellitus (NIDDM), we performed a genome-wide analysis for quantitative trait loci (QTLs) using 359 backcross progeny of the Otsuka Long-Evans Tokushima Fatty (OLETF) rat. The OLETF strain is a well-studied animal model of obese NIDDM, with features of hyperinsulinemia, hyperglycemia, insulin resistance, and abundant abdominal fat. Our extensive genomic scanning with 218 markers revealed nine significant QTLs, including a strong determinant of obesity on chromosome 1 (Dmo1: LOD = 13.99, for body weight). Two highly significant QTLs for glucose homeostasis were found, one on chromosome 1 (Dmo4 LOD = 7.16, for postprandial glucose level) and the other on chromosome X (Dmo11/Odb1: LOD = 7.81, for postprandial glucose level). These data are comparable to results of our previous studies of the OLETF rat.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/8800135
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Blood Glucose
pubmed:status	MEDLINE
pubmed:month	Jun
pubmed:issn	0888-7543
pubmed:author	pubmed-author:HishigakiHH, pubmed-author:IrieYY, pubmed-author:KanemotoNN, pubmed-author:Mizoguchi-MiyakitaAA, pubmed-author:NakamuraYY, pubmed-author:OgaKK, pubmed-author:OkunoSS, pubmed-author:TakagiTT, pubmed-author:TakahashiEE, pubmed-author:TanigamiAA, pubmed-author:TsujiAA, pubmed-author:WatanabeT KTK, pubmed-author:YamasakiYY
pubmed:copyrightInfo	Copyright 1999 Academic Press.
pubmed:issnType	Print
pubmed:day	15
pubmed:volume	58
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	233-9
pubmed:dateRevised	2010-11-18
pubmed:meshHeading	pubmed-meshheading:10373320-Adipose Tissue, pubmed-meshheading:10373320-Animals, pubmed-meshheading:10373320-Blood Glucose, pubmed-meshheading:10373320-Body Weight, pubmed-meshheading:10373320-Chromosome Mapping, pubmed-meshheading:10373320-Crosses, Genetic, pubmed-meshheading:10373320-Diabetes Mellitus, Type 2, pubmed-meshheading:10373320-Disease Models, Animal, pubmed-meshheading:10373320-Female, pubmed-meshheading:10373320-Genetic Linkage, pubmed-meshheading:10373320-Genotype, pubmed-meshheading:10373320-Lod Score, pubmed-meshheading:10373320-Male, pubmed-meshheading:10373320-Obesity, pubmed-meshheading:10373320-Phenotype, pubmed-meshheading:10373320-Quantitative Trait, Heritable, pubmed-meshheading:10373320-Rats, pubmed-meshheading:10373320-Rats, Inbred BN, pubmed-meshheading:10373320-Rats, Inbred OLETF, pubmed-meshheading:10373320-X Chromosome
pubmed:year	1999
pubmed:articleTitle	Genetic dissection of "OLETF," a rat model for non-insulin-dependent diabetes mellitus: quantitative trait locus analysis of (OLETF x BN) x OLETF.
pubmed:affiliation	Otsuka GEN Research Institute, Otsuka Pharmaceutical Co., Ltd., 463-10 Kagasuno, Kawauchi-cho, Tokushima, 771-0192, Japan.
pubmed:publicationType	Journal Article, Comparative Study