Source:http://linkedlifedata.com/resource/pubmed/id/10373244
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
1999-8-5
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| pubmed:abstractText |
The present study was designed to clarify the time-dependent changes in brain monoamine turnover in the frontal cortex, hypothalamus, hippocampus, septum and amygdala after ovariectomy, and the difference in behavioral responses to psychological stress between sham-operated and ovariectomized (OVX) rats. At 2 and 4 weeks after ovariectomy, the turnover rates of dopamine and norepinephrine in all of the brain regions examined did not differ significantly between the sham-operated and OVX rats. However, 5-hydroxytryptamine (5-HT) turnover in all of the brain regions at 2 weeks after OVX was significantly lower than that in sham-operated rats. This difference was greater in the hypothalamus than in other brain regions. At 4 weeks after ovariectomy, 5-HT turnover in all of the brain regions examined was not significantly different between sham-operated and OVX rats. At 2 and 4 weeks after ovariectomy, exploratory behaviour (e.g., locomotor activity, head- dipping, crossing and rearing behaviours) in a non-stressed ovariectomy group did not differ from that in a non-stressed sham-operation group. Locomotor activity and the number of head-dips and crossings significantly (P<0.05) increased after repeated exposure to psychological stress for 5 days in sham-operated rats, but not in those at 2 weeks after OVX. At 4 weeks after ovariectomy, locomotor activity and the number of crossings and rearings in sham-operated and OVX rats were not significantly different in the psychological stress and non-stress groups. However, the number of head-dips significantly (P<0.05) increased with psychological stress in the sham-operated rats, but not in OVX rats. These results suggest that female gonadal hormones may play an important role in the regulation of brain 5-HTergic systems. These interactions between gonadal hormones and 5-HT metabolism may be related to 5-HT-related neuropsychiatric disorders.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Jun
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| pubmed:issn |
1043-6618
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| pubmed:author | |
| pubmed:copyrightInfo |
Copyright 1999 Academic Press.
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| pubmed:issnType |
Print
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| pubmed:volume |
39
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
455-61
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| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:10373244-Amygdala,
pubmed-meshheading:10373244-Animals,
pubmed-meshheading:10373244-Behavior, Animal,
pubmed-meshheading:10373244-Brain,
pubmed-meshheading:10373244-Brain Chemistry,
pubmed-meshheading:10373244-Dopamine,
pubmed-meshheading:10373244-Exploratory Behavior,
pubmed-meshheading:10373244-Female,
pubmed-meshheading:10373244-Frontal Lobe,
pubmed-meshheading:10373244-Hippocampus,
pubmed-meshheading:10373244-Hypothalamus,
pubmed-meshheading:10373244-Norepinephrine,
pubmed-meshheading:10373244-Organ Size,
pubmed-meshheading:10373244-Ovariectomy,
pubmed-meshheading:10373244-Rats,
pubmed-meshheading:10373244-Rats, Sprague-Dawley,
pubmed-meshheading:10373244-Septum Pellucidum,
pubmed-meshheading:10373244-Serotonin,
pubmed-meshheading:10373244-Stress, Psychological,
pubmed-meshheading:10373244-Uterus,
pubmed-meshheading:10373244-Weight Gain
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| pubmed:year |
1999
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| pubmed:articleTitle |
Neurochemical characteristics and behavioral responses to psychological stress in ovariectomized rats.
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| pubmed:affiliation |
Department of Pharmacology, Tokyo Medical University, 6-1-1 Shinjuku, Tokyo, Shinjuku-ku, 160-8402, Japan.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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