Linked Life Data

10372930

Source:http://linkedlifedata.com/resource/pubmed/id/10372930

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1999-9-8
pubmed:abstractText
Technetium-99m-diethylenetriaminepentaacetic acid-galactosyl-human serum albumin (Tc-GSA) is a receptor binding agent, specific for asialoglycoprotein receptor, that resides exclusively on the plasma membrane of mammalian hepatocytes. The usefulness of Tc-GSA for estimating the hepatic functional reserve was retrospectively evaluated in patients undergoing a hepatic resection. Tc-GSA scintigraphy was performed in 35 patients before hepatectomy, and the hepatic uptake ratio (LHL15) was calculated. The LHL15 was then compared with the findings of conventional liver function tests, the indocyanine green retention rate in 15 minutes (ICG R15), and histologic activity index (HAI) score. Significant correlations were observed between the LHL15 and values of ICG R15, prothrombin time activity, serum levels of total bilirubin, hyaluronic acid, and values of HAI score. Ratios of LHL15 to preoperative liver volume (LHL-V) correlated well with the regenerative rates of the residual liver after major hepatectomy. In addition, patients with more than 0.76 of LHL-V value had no complications in postoperative course, whereas those with less than 0.73 had several complications due to hepatic dysfunction. Tc-GSA scintigraphy thus appears to be a useful diagnostic tool for evaluating functioning mass of the liver and the values of LHL-V seems to be able to demonstrate regenerative activity in the residual liver after hepatectomy.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0192-0790
pubmed:author
pubmed:issnType
Print
pubmed:volume
28
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
329-33
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:10372930-Adult, pubmed-meshheading:10372930-Aged, pubmed-meshheading:10372930-Aged, 80 and over, pubmed-meshheading:10372930-Female, pubmed-meshheading:10372930-Hepatectomy, pubmed-meshheading:10372930-Humans, pubmed-meshheading:10372930-Indocyanine Green, pubmed-meshheading:10372930-Linear Models, pubmed-meshheading:10372930-Liver, pubmed-meshheading:10372930-Liver Function Tests, pubmed-meshheading:10372930-Liver Neoplasms, pubmed-meshheading:10372930-Liver Regeneration, pubmed-meshheading:10372930-Male, pubmed-meshheading:10372930-Middle Aged, pubmed-meshheading:10372930-Postoperative Complications, pubmed-meshheading:10372930-Radiopharmaceuticals, pubmed-meshheading:10372930-Technetium Tc 99m Aggregated Albumin, pubmed-meshheading:10372930-Technetium Tc 99m Pentetate
pubmed:year
1999
pubmed:articleTitle
Utility of technetium-99m-labeled-galactosyl human serum albumin scintigraphy for estimating the hepatic functional reserve.
pubmed:affiliation
Department of Surgery II, Nagasaki University School of Medicine, Japan.
pubmed:publicationType
Journal Article, Comparative Study