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rdf:type |
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lifeskim:mentions |
umls-concept:C0043393,
umls-concept:C0162796,
umls-concept:C0205314,
umls-concept:C0679622,
umls-concept:C0728938,
umls-concept:C1514873,
umls-concept:C1521761,
umls-concept:C1546857,
umls-concept:C1556066,
umls-concept:C1619636,
umls-concept:C1622990,
umls-concept:C1706853,
umls-concept:C1879748,
umls-concept:C1998793
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pubmed:issue |
12
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pubmed:dateCreated |
1999-8-19
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pubmed:abstractText |
We have partially purified the U2 snRNP of Saccharomyces cerevisiae. Identification of some proteins consistently found in the purified fractions by nanoelectrospray mass spectrometry indicated the presence of a novel splicing factor named Rse1p. The RSE1 gene is essential and codes for a 148.2 kDa protein. We demonstrated that Rse1p associates specifically with U2 snRNA at low salt concentrations. In addition, we showed that Rse1p is a component of the pre-spliceosome. Depletion of Rse1p and analysis of a conditional mutant indicated that Rse1p was required for efficient splicing in vivo. In vitro Rse1p is required for the formation of pre-spliceosomes. Database searches revealed that Rse1p is conserved in humans and that it belongs to a large protein family that includes polyadenylation factors and DNA repair proteins. The characteristics of Rse1p suggest that its human homologue could be a subunit of the SF3 splicing factor.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/10369685-10369684,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10369685-1387205,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10369685-1398075,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10369685-1406644,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10369685-1538748,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10369685-1752442,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10369685-1756731,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10369685-1827069,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10369685-1827409,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10369685-1836445,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10369685-1882420,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10369685-2529976,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10369685-2560755,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10369685-2684770,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10369685-3056718,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10369685-3192077,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10369685-3888403,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10369685-6308621,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10369685-6546423,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10369685-7489498,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10369685-7590244,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10369685-7651824,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10369685-7744014,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10369685-7922333,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10369685-7926772,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10369685-7958871,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10369685-8022796,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10369685-8036511,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10369685-8164655,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10369685-8211112,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10369685-8211113,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10369685-8211114,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10369685-8299163,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10369685-8349644,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10369685-8367487,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10369685-8371985,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10369685-8380223,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10369685-8405998,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10369685-8407968,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10369685-8530102,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10369685-8566755,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10369685-8566756,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10369685-8649387,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10369685-8710499,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10369685-8718683,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10369685-8722179,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10369685-8779426,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10369685-8779443,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10369685-8811105,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10369685-8811184,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10369685-8846293,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10369685-8929410,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10369685-9009836,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10369685-9012791,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10369685-9150140,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10369685-9159080,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10369685-9207794,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10369685-9396791,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10369685-9436903,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10369685-9436997,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10369685-9476892,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10369685-9512519,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10369685-9585501,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10369685-9630245,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10369685-9671485,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10369685-9778799,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10369685-9799242,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10369685-9819400
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0261-4189
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pubmed:author |
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