| pubmed-article:10369663 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10369663 | lifeskim:mentions | umls-concept:C0036098 | lld:lifeskim |
| pubmed-article:10369663 | lifeskim:mentions | umls-concept:C0678544 | lld:lifeskim |
| pubmed-article:10369663 | lifeskim:mentions | umls-concept:C0596235 | lld:lifeskim |
| pubmed-article:10369663 | lifeskim:mentions | umls-concept:C0086597 | lld:lifeskim |
| pubmed-article:10369663 | lifeskim:mentions | umls-concept:C0441712 | lld:lifeskim |
| pubmed-article:10369663 | lifeskim:mentions | umls-concept:C0322495 | lld:lifeskim |
| pubmed-article:10369663 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:10369663 | pubmed:dateCreated | 1999-8-19 | lld:pubmed |
| pubmed-article:10369663 | pubmed:abstractText | Intercellular Ca2+ signaling in intact salivary glands of the blowfly Calliphora erythrocephala was studied by fluorimetric digital imaging combined with microinjection of putative messenger molecules. Iontophoretic injection of D-myo-inositol 1,4, 5-trisphosphate (InsP3) into salivary gland cells evoked regenerative intercellular Ca2+ waves that spread through the impaled cell and several rows of surrounding cells. Ca2+ increases induced by microinjection of Ca2+ ions were confined to the injected cells and their nearest neighbors. Depletion of intracellular Ca2+ stores by thapsigargin pre-treatment did not alter the time course of the Ca2+ increase caused by Ca2+ injection. However, activation of Ca2+ release became clearly evident when Ca2+ was injected in the presence of serotonin (5-HT). Under these conditions, injection of Ca2+ triggered intercellular Ca2+ waves that consecutively passed through >10 cells. The phospholipase C inhibitor U73122 blocked 5-HT-induced Ca2+ increases but did not affect InsP3-dependent Ca2+ spiking and intercellular Ca2+ wave propagation. The results demonstrate that propagation of agonist-evoked Ca2+ waves in the blowfly salivary gland requires supra-basal [InsP3] but does not depend on feedback activation of phospholipase C. We conclude that the intra- and intercellular transmission of these Ca2+ waves is mediated by diffusion of Ca2+ and Ca2+-induced Ca2+ release via the InsP3 receptor channel. | lld:pubmed |
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| pubmed-article:10369663 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10369663 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10369663 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10369663 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:10369663 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10369663 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:10369663 | pubmed:issn | 0261-4189 | lld:pubmed |
| pubmed-article:10369663 | pubmed:author | pubmed-author:ZimmermannBB | lld:pubmed |
| pubmed-article:10369663 | pubmed:author | pubmed-author:WallPP | lld:pubmed |
| pubmed-article:10369663 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10369663 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:10369663 | pubmed:volume | 18 | lld:pubmed |
| pubmed-article:10369663 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10369663 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10369663 | pubmed:pagination | 3222-31 | lld:pubmed |
| pubmed-article:10369663 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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