Linked Life Data

10368716

Source:http://linkedlifedata.com/resource/pubmed/id/10368716

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
19
pubmed:dateCreated
1999-7-2
pubmed:abstractText
In spite of the collection in the last 50 years of an enormous amount of knowledge about aetiology and pathogenesis of autoimmune diseases, important questions have not yet been answered (adequately), as shown by the very limited therapeutic application of this knowledge. Although autoreactive B and T cells are demonstrable in healthy individuals, this does under normal circumstances not lead to disease, for instance because necessary co-factors are lacking, B lymphocytes for antibody production require help from suitable autoreactive T helper cells, because of the action of T suppressor cells and due to anti-idiotypic antibodies and T cell receptors that may be directed against the antigen receptors of autoreactive B and T cells. Autoimmune diseases are sometimes subdivided into organspecific (e.g. Graves' disease) and systemic autoimmune diseases (e.g. disseminated lupus erythematosus). Roughly speaking there are two hypotheses concerning the aetiology or development of autoimmune diseases. The first hypothesis assumes a specific antigen as the driving factor, the second dysregulation of the immune system. The new insights into the pathogenesis of autoimmune diseases so far led to development of only few new drugs or therapies.
pubmed:language
dut
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0028-2162
pubmed:author
pubmed:issnType
Print
pubmed:day
8
pubmed:volume
143
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
974-8
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1999
pubmed:articleTitle
[Immunology in medical practice. XIX. Etiology and pathogenesis of auto-immune diseases].
pubmed:affiliation
Leids Universitair Medisch Centrum, afd. Immunohematologie en Bloedbank, Leiden.
pubmed:publicationType
Journal Article, English Abstract, Review