Linked Life Data

10368644

Source:http://linkedlifedata.com/resource/pubmed/id/10368644

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2A
pubmed:dateCreated
1999-7-1
pubmed:abstractText
We have investigated the effect of hyperthermia (HT) treatment on the extent of etoposide-induced apoptosis in human leukemia HL-60 cells. The cells were heated at 43 degrees C for 15 to 60 min. Relative quantitative changes in the apoptotic (Ap) fractions were monitored by flow cytometry, HT treatment for 15 min prior to or concurrently with etoposide exposure had no effect on the Ap fraction generated by the drug alone, whereas, 60 min heating resulted in an increase in the Ap fraction. Heating of the cells at 6 to 24 hr after drug exposure enhanced the Ap fraction. Taken collectively, the results indicate that appropriately scheduled HT and etoposide treatments may lead to a thermochemotherapy protocol that will result in increased etoposide-induced death of human leukemia cells.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0250-7005
pubmed:author
pubmed:issnType
Print
pubmed:volume
19
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
995-8
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:articleTitle
Schedule-dependent efficiency of thermochemotherapy in vitro with etoposide and heating at 43 degrees C.
pubmed:affiliation
Department of Molecular Biology, Cell Biology and Biochemistry, J.W. Wilson Laboratory, Brown University, Providence, RI 02912, USA. pantazis@brown.edu
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S.