|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
5
|
|
pubmed:dateCreated |
1999-7-23
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|
pubmed:abstractText |
Nucleoside analogues such as lamivudine and famciclovir are potent drugs for treatment of chronic hepatitis B virus infection. Breakthrough infections during lamivudine therapy are associated with mutations in the YMDD motif and putative B region of the HBV polymerase. This study investigated whether failure of famciclovir therapy is also associated with presence or emergence of particular mutations in the HBV polymerase.
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pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
May
|
|
pubmed:issn |
0168-8278
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
30
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
749-54
|
|
pubmed:dateRevised |
2008-11-21
|
|
pubmed:meshHeading |
pubmed-meshheading:10365797-2-Aminopurine,
pubmed-meshheading:10365797-Amino Acid Sequence,
pubmed-meshheading:10365797-Amino Acid Substitution,
pubmed-meshheading:10365797-Antiviral Agents,
pubmed-meshheading:10365797-DNA Replication,
pubmed-meshheading:10365797-Gene Products, pol,
pubmed-meshheading:10365797-Genetic Variation,
pubmed-meshheading:10365797-Genotype,
pubmed-meshheading:10365797-Hepatitis B,
pubmed-meshheading:10365797-Hepatitis B virus,
pubmed-meshheading:10365797-Humans,
pubmed-meshheading:10365797-Longitudinal Studies,
pubmed-meshheading:10365797-Molecular Sequence Data,
pubmed-meshheading:10365797-Polymerase Chain Reaction,
pubmed-meshheading:10365797-RNA-Directed DNA Polymerase,
pubmed-meshheading:10365797-Sequence Alignment,
pubmed-meshheading:10365797-Treatment Failure
|
|
pubmed:year |
1999
|
|
pubmed:articleTitle |
Absence of mutations in the YMDD motif/B region of the hepatitis B virus polymerase in famciclovir therapy failure.
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|
pubmed:affiliation |
Heinrich-Pette-Institut für Experimentelle Virologie und Immunologie an der Universität, Hamburg, Federal Republic of Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
