Source:http://linkedlifedata.com/resource/pubmed/id/10365637
Switch to
Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
|
pubmed:dateCreated |
1999-8-3
|
pubmed:abstractText |
The population pharmacokinetics of gentamicin and tobramycin were investigated in a group of 51 young adults with cystic fibrosis. Their ages ranged from 14-35 years, weights from 38-82 kg, and 27 of the patients were female. None of the patients had renal impairment, but 3 patients were treated in the intensive therapy unit (ITU) during one of their courses of therapy. Data comprised 219 courses of therapy and 544 concentrations (mean: 11 per patient). Concentration-time data were analyzed using a nonlinear mixed-effects model package (NONMEM) and were best described by a one-compartment model. Factors identified as potentially influencing aminoglycoside pharmacokinetics were added in a stepwise fashion and the best model found that drug clearance and volume of distribution were related to body surface area and admission to ITU. The mean population estimates were a clearance of 2.89 L/hr/m2 and a volume of distribution of 9.21 L/m2 with a 60% increase in patients who were admitted to ITU. Interpatient variability in clearance and volume were 14% and 8%, respectively. The results suggested that a dose of 120 mg/m2 should achieve an average 1 hour postdose peak of 10 mg/L and trough of <1 mg/L and that higher doses might be required in ITU patients.
|
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Jun
|
pubmed:issn |
0163-4356
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
21
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
281-8
|
pubmed:dateRevised |
2004-11-17
|
pubmed:meshHeading |
pubmed-meshheading:10365637-Adolescent,
pubmed-meshheading:10365637-Adult,
pubmed-meshheading:10365637-Aminoglycosides,
pubmed-meshheading:10365637-Anti-Bacterial Agents,
pubmed-meshheading:10365637-Cystic Fibrosis,
pubmed-meshheading:10365637-Dose-Response Relationship, Drug,
pubmed-meshheading:10365637-Female,
pubmed-meshheading:10365637-Humans,
pubmed-meshheading:10365637-Linear Models,
pubmed-meshheading:10365637-Male,
pubmed-meshheading:10365637-Metabolic Clearance Rate,
pubmed-meshheading:10365637-Population Surveillance
|
pubmed:year |
1999
|
pubmed:articleTitle |
Population pharmacokinetics of aminoglycoside antibiotics in patients with cystic fibrosis.
|
pubmed:affiliation |
Pharmacy Department, West Glasgow Hospitals Trust, University of Strathclyde, Scotland.
|
pubmed:publicationType |
Journal Article
|