Linked Life Data

10365443

Source:http://linkedlifedata.com/resource/pubmed/id/10365443

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1999-7-9
pubmed:abstractText
The chelator 2,2'-dipyridyl (0.2 mM) induces a remarkable increase of protoporphyrin IX concentration as well as of its Zn-containing complex in the yeast Saccharomyces cerevisiae. Endogenous porphyrin accumulation results in five- to six-fold cell sensitization to visible light (400-600 nm). Mitochondria isolated from the cells grown in the presence of 2,2'-dipyridyl accumulate protoporphyrin IX and Zn-protoporphyrin IX, while plasma membranes besides that exhibit porphyrin-type fluorescence at 670-675 nm in chloroform extract. The protoporphyrin IX content increases more than four-fold in mitochondria and two-fold in plasma membranes isolated from chelator-treated cells. The relative contribution of subcellular structure photodestruction to photoinduced cell inactivation is discussed.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
1011-1344
pubmed:author
pubmed:issnType
Print
pubmed:volume
49
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
18-22
pubmed:dateRevised
2007-7-23
pubmed:meshHeading
pubmed:year
1999
pubmed:articleTitle
Endogenous porphyrin accumulation and photosensitization in the yeast Saccharomyces cerevisiae in the presence of 2,2'-dipyridyl.
pubmed:affiliation
Department of Biophysics, Faculty of Biology, M.V. Lomonosov Moscow State University, Russia.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't