| pubmed-article:10364449 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10364449 | lifeskim:mentions | umls-concept:C0242617 | lld:lifeskim |
| pubmed-article:10364449 | lifeskim:mentions | umls-concept:C1418275 | lld:lifeskim |
| pubmed-article:10364449 | lifeskim:mentions | umls-concept:C1148673 | lld:lifeskim |
| pubmed-article:10364449 | lifeskim:mentions | umls-concept:C1709450 | lld:lifeskim |
| pubmed-article:10364449 | lifeskim:mentions | umls-concept:C0871161 | lld:lifeskim |
| pubmed-article:10364449 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:10364449 | pubmed:dateCreated | 1999-7-16 | lld:pubmed |
| pubmed-article:10364449 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10364449 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10364449 | pubmed:abstractText | Transcription factors Pax-4 and Pax-6 are known to be key regulators of pancreatic cell differentiation and development. We report on the cloning of a mouse Pax-4 gene, which contains 10 exons, spanning a 4. 7-kbp region. The gene-targeting experiments revealed that Pax-4 and Pax-6 cannot substitute for each other in tissue with overlapping expression of both genes. We identified DNA-binding specificities of Pax-4 paired domain and paired-type homeodomain. Despite the different Pax-4 amino acid residues in positions responsible for Pax-6 paired-domain specificity, the DNA-binding specificities of Pax-4 and Pax-6 are similar. The Pax-4 homeodomain was shown to preferentially dimerize on DNA sequences consisting of an inverted TAAT motif, separated by 4-nucleotide spacing. The Pax-4 transactivation domain was localized within its C-terminal region, which transactivated GAL-based reporter 2.5-fold less than the C-terminal region of Pax-6. We believe that Pax-4 can act as a Pax-6 "repressor," due to the competition for binding sites and lower transactivation potential of Pax-4. | lld:pubmed |
| pubmed-article:10364449 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10364449 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10364449 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10364449 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:10364449 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10364449 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10364449 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:10364449 | pubmed:issn | 0006-291X | lld:pubmed |
| pubmed-article:10364449 | pubmed:author | pubmed-author:BenesVV | lld:pubmed |
| pubmed-article:10364449 | pubmed:author | pubmed-author:PacesVV | lld:pubmed |
| pubmed-article:10364449 | pubmed:author | pubmed-author:KozmikZZ | lld:pubmed |
| pubmed-article:10364449 | pubmed:author | pubmed-author:PacesJJ | lld:pubmed |
| pubmed-article:10364449 | pubmed:author | pubmed-author:KalousováAA | lld:pubmed |
| pubmed-article:10364449 | pubmed:copyrightInfo | Copyright 1999 Academic Press. | lld:pubmed |
| pubmed-article:10364449 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10364449 | pubmed:day | 16 | lld:pubmed |
| pubmed-article:10364449 | pubmed:volume | 259 | lld:pubmed |
| pubmed-article:10364449 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10364449 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10364449 | pubmed:pagination | 510-8 | lld:pubmed |
| pubmed-article:10364449 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:10364449 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10364449 | pubmed:articleTitle | DNA binding and transactivating properties of the paired and homeobox protein Pax4. | lld:pubmed |
| pubmed-article:10364449 | pubmed:affiliation | Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, Prague, Czech Republic. Anna@biomed.cas.cz | lld:pubmed |
| pubmed-article:10364449 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10364449 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:18506 | entrezgene:pubmed | pubmed-article:10364449 | lld:entrezgene |
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