|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
7
|
|
pubmed:dateCreated |
1999-7-23
|
|
pubmed:abstractText |
Human immunodeficiency virus type 1 (HIV-1) amino acid substitutions observed during antiretroviral drug therapy may be caused by drug selection, non-drug-related evolution, or sampling error introduced by the sequencing process. We analyzed HIV-1 sequences from 371 untreated patients and from 178 patients receiving a single protease inhibitor. Amino acid substitution patterns during treatment were compared with inferred substitution patterns arising evolutionarily without treatment. Our results suggest that most treatment-associated amino acid substitutions are caused by selective drug pressure, including substitutions not previously associated with drug resistance.
|
|
pubmed:grant |
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/10364383-10024054,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10364383-7824947,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10364383-8633817,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10364383-8673920,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10364383-8673921,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10364383-8844016,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10364383-8853733,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10364383-8970946,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10364383-9261388,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10364383-9732064,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10364383-9756769,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10364383-9764779,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10364383-9847225
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jul
|
|
pubmed:issn |
0022-538X
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
73
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
6197-202
|
|
pubmed:dateRevised |
2009-11-18
|
|
pubmed:meshHeading |
pubmed-meshheading:10364383-Amino Acid Sequence,
pubmed-meshheading:10364383-Amino Acid Substitution,
pubmed-meshheading:10364383-Anti-HIV Agents,
pubmed-meshheading:10364383-Genetic Variation,
pubmed-meshheading:10364383-HIV Infections,
pubmed-meshheading:10364383-HIV Protease,
pubmed-meshheading:10364383-HIV Protease Inhibitors,
pubmed-meshheading:10364383-HIV-1,
pubmed-meshheading:10364383-Humans,
pubmed-meshheading:10364383-Indinavir,
pubmed-meshheading:10364383-Molecular Sequence Data,
pubmed-meshheading:10364383-Nelfinavir,
pubmed-meshheading:10364383-Ritonavir,
pubmed-meshheading:10364383-Saquinavir
|
|
pubmed:year |
1999
|
|
pubmed:articleTitle |
Identification of biased amino acid substitution patterns in human immunodeficiency virus type 1 isolates from patients treated with protease inhibitors.
|
|
pubmed:affiliation |
Division of Infectious Diseases, Stanford University Medical Center, Stanford, California 94305, USA. rshafer@cmgm.stanford.edu
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|
