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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
1999-7-12
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pubmed:abstractText |
The cellular basis of graft rejection and the development of strategies for specific suppression of T cell responses against allogeneic and xenogeneic transplants represents an area of active investigation. Recently, a population of MHC-class I restricted CD8+CD28- T suppressor cells (Ts) which are able to inhibit specifically the proliferative response of allospecific, xenospecific and nominal-antigen specific CD4+ T helper cells (Th) has been identified. We have studied the TCR V beta gene repertoire expressed by CD8+CD28- Ts isolated from allospecific, xenospecific, and nominal antigen-specific T cell lines (TCL). A limited V beta repertoire has been found in all TCLs studied. The most restricted TCR V beta usage was observed within the population of Ts from xenospecific TCLs. The TCR V beta usage within the Ts subset of TCL differs from the TCR repertoire expressed by the CD4+ Th subset of the same TCL. This is consistent with the fact that Ts and Th cells recognize distinct MHC/ antigen complexes. The finding that the TCR repertoire used by Ts is limited opens new avenues for studying the mechanisms of transplant rejection.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD28,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD8,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Heterophile,
http://linkedlifedata.com/resource/pubmed/chemical/Epitopes, T-Lymphocyte,
http://linkedlifedata.com/resource/pubmed/chemical/Isoantigens,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Antigen, T-Cell...
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0198-8859
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
60
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
291-304
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:10363720-Animals,
pubmed-meshheading:10363720-Antigens, CD28,
pubmed-meshheading:10363720-Antigens, CD8,
pubmed-meshheading:10363720-Antigens, Heterophile,
pubmed-meshheading:10363720-Cell Line,
pubmed-meshheading:10363720-Epitopes, T-Lymphocyte,
pubmed-meshheading:10363720-Gene Rearrangement, beta-Chain T-Cell Antigen Receptor,
pubmed-meshheading:10363720-Humans,
pubmed-meshheading:10363720-Isoantigens,
pubmed-meshheading:10363720-Lymphocyte Activation,
pubmed-meshheading:10363720-Multigene Family,
pubmed-meshheading:10363720-Polymerase Chain Reaction,
pubmed-meshheading:10363720-Receptors, Antigen, T-Cell, alpha-beta,
pubmed-meshheading:10363720-Swine,
pubmed-meshheading:10363720-Swine, Miniature,
pubmed-meshheading:10363720-T-Lymphocyte Subsets,
pubmed-meshheading:10363720-T-Lymphocytes, Regulatory
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pubmed:year |
1999
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pubmed:articleTitle |
TCR repertoire of suppressor CD8+CD28- T cell populations.
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pubmed:affiliation |
Department of Pathology, College of Physicians and Surgeons of Columbia University, New York 10032, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study
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