rdf:type |
|
lifeskim:mentions |
umls-concept:C0023688,
umls-concept:C0029246,
umls-concept:C0033684,
umls-concept:C0337611,
umls-concept:C0678594,
umls-concept:C0681494,
umls-concept:C1514562,
umls-concept:C1552657,
umls-concept:C1552720,
umls-concept:C1880389,
umls-concept:C1883204,
umls-concept:C1883221,
umls-concept:C2728259
|
pubmed:issue |
5
|
pubmed:dateCreated |
1999-7-21
|
pubmed:abstractText |
A program is described for automatically generating schematic linear representations of protein chains in terms of their structural domains. The program requires the co-ordinates of the chain, the domain assignment, PROSITE information and a file listing all intermolecular interactions in the protein structure. The output is a PostScript file in which each protein is represented by a set of linked boxes, each box corresponding to all or part of a structural domain. PROSITE motifs and residues involved in ligand interactions are highlighted. The diagrams allow immediate visualization of the domain arrangement within a protein chain, and by providing information on sequence motifs, and metal ion, ligand and DNA binding at the domain level, the program facilitates detection of remote evolutionary relationships between proteins.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
May
|
pubmed:issn |
0269-2139
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
12
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
375-9
|
pubmed:dateRevised |
2006-11-15
|
pubmed:meshHeading |
pubmed-meshheading:10360977-Adenosine Diphosphate,
pubmed-meshheading:10360977-Amino Acid Sequence,
pubmed-meshheading:10360977-Animals,
pubmed-meshheading:10360977-DNA-Binding Proteins,
pubmed-meshheading:10360977-Databases, Factual,
pubmed-meshheading:10360977-Evolution, Molecular,
pubmed-meshheading:10360977-HSP70 Heat-Shock Proteins,
pubmed-meshheading:10360977-Internet,
pubmed-meshheading:10360977-Ligands,
pubmed-meshheading:10360977-Models, Molecular,
pubmed-meshheading:10360977-Molecular Sequence Data,
pubmed-meshheading:10360977-Proteins,
pubmed-meshheading:10360977-Software,
pubmed-meshheading:10360977-Triose-Phosphate Isomerase
|
pubmed:year |
1999
|
pubmed:articleTitle |
DOMPLOT: a program to generate schematic diagrams of the structural domain organization within proteins, annotated by ligand contacts.
|
pubmed:affiliation |
Biomolecular Structure and Modelling Unit, Department of Biochemistry and Molecular Biology, University College London, Gower Street, London WC1E 6BT, UK.
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|