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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
1999-7-22
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pubmed:abstractText |
The in vitro activities of 3-hydroxy-imidazolidin-4-one derivatives demonstrated very restricted structure-activity relationships at the strychnine-insensitive glycine site of the NMDA receptor. The most active compound (3a) was completely unsubstituted and exhibited affinity and efficacy similar to that of D-cycloserine, the prototypical partial agonist at this site.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0960-894X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
17
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pubmed:volume |
9
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1409-14
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pubmed:dateRevised |
2000-12-18
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pubmed:meshHeading |
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pubmed:year |
1999
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pubmed:articleTitle |
Design, synthesis and structure-activity relationships of novel strychnine-insensitive glycine receptor ligands.
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pubmed:affiliation |
Institut de Recherches Servier, Suresnes, France. cordi@netgrs.com
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pubmed:publicationType |
Journal Article
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