Linked Life Data

10355044

Source:http://linkedlifedata.com/resource/pubmed/id/10355044

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1999-8-12
pubmed:abstractText
Cloning, functional characterisation, and diagnostic proof of the expression of sodium-iodide-symporter (NIS) in the thyroid are essential steps for a better understanding of function and regulation of thyroid hormone synthesis, which is limited by the availability of the trace element iodide. The physiological or pharmacological modulation of NIS function can now be used for a rational functional diagnosis and therapy of thyroid diseases. Diagnostic procedures based on analysis of the this gene or its expression are already in use for the analysis of benign and malignant alterations of the thyroid. Experimental protocols aiming at the functional expression of NIS in thyroid tumors or their metastases which lost capability for iodide uptake are currently developed. Furthermore, techniques are under investigation to express functional NIS by gene transfer in those benign or malignant tissues, tumors, metastases, which normally do not accumulate iodide. This would allow application of radioiodide therapy, a save and established technique to non-thyroid-related fatal diseases.
pubmed:language
ger
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
1431-7621
pubmed:author
pubmed:issnType
Print
pubmed:volume
93 Suppl 1
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
17-22
pubmed:dateRevised
2008-11-3
pubmed:meshHeading
pubmed:year
1999
pubmed:articleTitle
[The sodium-iodide-symporter (NIS): function, regulation and clinical importance].
pubmed:affiliation
Abteilung für Molekulare Innere Medizin, Universität Würzburg. J.KOEHRLE@MAIL.UNI-WUERZBURG.DE
pubmed:publicationType
Journal Article, English Abstract, Review, Research Support, Non-U.S. Gov't