Linked Life Data

10354690

Source:http://linkedlifedata.com/resource/pubmed/id/10354690

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7-8
pubmed:dateCreated
1999-7-15
pubmed:abstractText
From the theoretical point of view, food intake exerts a complex influence on the bioavailability of drugs. It may interfere with tablet disintegration, drug dissolution and drug transit through the gastrointestinal tract, may also affect the metabolic transformation of drugs in the gastrointestinal wall and the liver. The knowledge about the influence of food is very important in treatment of tuberculosis, where the drugs are taken once daily or even less frequently. We studied the isoniazid concentrations in blood serum of 20 volunteers (12 slow and 8 fast acetylators of INH) both sexes, after the drug intake 2 hours before breakfast and immediately after breakfast. Concentrations of INH were tested by biological method with Mycobacterium aurum REB as a standard strain. The results have shown, that Cmax (3.55 +/- 0.29 versus 2.56 +/- 0.49 in fast acetylators and 4.34 +/- 0.2 versus 3.67 +/- 0.37 in slow acetylators), tmax (0.75 +/- 0.26 versus 1.31 +/- 0.37 in fast acetylators and 0.87 +/- 0.31 versus 1.79 +/- 0.62 in slow acetylators and AUC0-t (6.6 +/- 1.34 versus 5.47 +/- 1.5 in fast acetylators and 21.82 +/- 2.57 versus 18.61 +/- 2.57 in slow acetylators) are significantly decreased after ingestion of INH with breakfast.
pubmed:language
pol
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0867-7077
pubmed:author
pubmed:issnType
Print
pubmed:volume
66
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
412-21
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1998
pubmed:articleTitle
[Influence of food on the bioavailability of isoniazid in health volunteers].
pubmed:affiliation
Zak?adu Mikrobiologii, Instytutu Gru?licy i Chorób P?uc w Warszawie.
pubmed:publicationType
Journal Article, Clinical Trial, English Abstract