Source:http://linkedlifedata.com/resource/pubmed/id/10354567
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
6
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pubmed:dateCreated |
1999-7-14
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pubmed:abstractText |
Compartmentalization of signalling molecules through association with anchoring proteins ensures specificity in signal transduction by placing enzymes close to their appropriate effectors and substrates. For example, 'A-kinase anchoring proteins' (AKAPs) bind to the regulatory subunit of cAMP-dependent protein kinase (PKA) to direct the kinase to discrete intracellular locations. Recently, functional studies aimed at disrupting AKAP-PKA complexes have demonstrated a role for anchored PKA in various cellular processes, including gene transcription, hormone-mediated insulin secretion and ion-channel modulation. By binding to additional signalling molecules, AKAPs might function to coordinate multiple components of signal-transduction pathways.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0962-8924
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
9
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
216-21
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:10354567-Carrier Proteins,
pubmed-meshheading:10354567-Cell Compartmentation,
pubmed-meshheading:10354567-Cyclic AMP,
pubmed-meshheading:10354567-Cyclic AMP-Dependent Protein Kinases,
pubmed-meshheading:10354567-Membrane Proteins,
pubmed-meshheading:10354567-Protein Binding,
pubmed-meshheading:10354567-Signal Transduction
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pubmed:year |
1999
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pubmed:articleTitle |
AKAPs: from structure to function.
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pubmed:affiliation |
Howard Hughes Medical Institute, L-474, Vollum Institute, Oregon Health Sciences University, 3181 SW Sam Jackson Park Road, Portland, OR 97201, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Review
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