Source:http://linkedlifedata.com/resource/pubmed/id/10353854
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1999-7-29
|
| pubmed:databankReference | |
| pubmed:abstractText |
A role for polyomaviruses in the pathogenesis of systemic lupus erythematosus (SLE) has been suggested. BK virus (BKV) and JC virus (JCV) were demonstrated in single urine specimens from 7 (16%) of 44 and 5 (11%) of 44 patients with SLE and 0/88 and 18 (21%) of 88 matched healthy controls, respectively. During a 1-year follow-up study, episodes of polyomaviruria were detected in 16 (80%) of 20 patients, BKV in 13, and JCV in 3 patients. A group of 12 (60%) of 20 patients demonstrated persistent or recurrent polyomaviruria, BKV viruria (n=9), or JCV viruria (n=3) in 180 (70%) of 256 specimens. Polyomaviruria was not significantly associated with immunosuppressive therapy. The BKV and JCV isolates revealed predominantly stable archetypal regulatory regions over 3 years, indicating viral persistence rather than reinfection as a cause for urinary shedding. The demonstration of nondetectable viremia and stable archetypal BKV and JCV noncoding control regions during persistent viruria argue against the urinary tract as a focus for the creation of rearranged regulatory region variants.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jul
|
| pubmed:issn |
0022-1899
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
180
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1-9
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| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:10353854-Adult,
pubmed-meshheading:10353854-Aged,
pubmed-meshheading:10353854-BK Virus,
pubmed-meshheading:10353854-Cross-Sectional Studies,
pubmed-meshheading:10353854-DNA, Viral,
pubmed-meshheading:10353854-Female,
pubmed-meshheading:10353854-Humans,
pubmed-meshheading:10353854-Immunosuppression,
pubmed-meshheading:10353854-JC Virus,
pubmed-meshheading:10353854-Kidney,
pubmed-meshheading:10353854-Lupus Erythematosus, Systemic,
pubmed-meshheading:10353854-Male,
pubmed-meshheading:10353854-Middle Aged,
pubmed-meshheading:10353854-Papillomavirus Infections,
pubmed-meshheading:10353854-Prevalence,
pubmed-meshheading:10353854-Regulatory Sequences, Nucleic Acid,
pubmed-meshheading:10353854-Sequence Analysis, DNA,
pubmed-meshheading:10353854-Sequence Homology, Nucleic Acid,
pubmed-meshheading:10353854-Tumor Virus Infections,
pubmed-meshheading:10353854-Viremia,
pubmed-meshheading:10353854-Virus Shedding
|
| pubmed:year |
1999
|
| pubmed:articleTitle |
BK and JC viruses in patients with systemic lupus erythematosus: prevalent and persistent BK viruria, sequence stability of the viral regulatory regions, and nondetectable viremia.
|
| pubmed:affiliation |
Department of Medical Microbiology, Institute of Medical Biology, University of Tromso, N-9037 Norway. arnfinns@fagmed.uit.no
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|