Source:http://linkedlifedata.com/resource/pubmed/id/10353500
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1-2
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| pubmed:dateCreated |
1999-7-15
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| pubmed:abstractText |
Few surveys have been performed to define the characteristics and impact of breakthrough pain in the cancer population. In this cross-sectional survey of inpatients with cancer, patients responded to a structured interview (the Breakthrough Pain Questionnaire) designed to characterize breakthrough pain, and also completed measures of pain and mood (Memorial Pain Assessment Card (MPAC)), pain-related interference in function (Brief Pain Inventory (BPI)), depressed mood (Beck Depression Inventory (BDI)), and anxiety (Beck Anxiety Inventory (BAI)). Of 178 eligible patients, 164 (92.2%) met the criteria for controlled background pain. The median age was 50.6 years (range 26 to 77 years), 52% were men, and 80.6% were Caucasian. Tumor diagnoses were mixed, 75% had metastatic disease, 65% had pain caused directly by the neoplasm, and a majority had mixed nociceptive-neuropathic pain. The median Karnofsky Performance Status score was 60 (range 40 to 90). Eighty-four (51.2%) patients had experienced breakthrough pain during the previous day. The median number of episodes was six (range 1 to 60) and the median interval from onset to peak was 3 min (range 1 s to 30 min). Although almost two-thirds (61.7%) could identify precipitants (movement 20.4%; end-of-dose failure 13.2%), pain was unpredictable in a large majority (78.2%). Patients with breakthrough pain had more intense (P < 0.001) and more frequent (P < 0.01) background pain than patients without breakthrough pain. Breakthrough pain was also associated with greater pain-related functional impairment (difference in mean BPI. P < 0.001), worse mood (mood VAS, P < 0.05; BDI, P < 0.001), and more anxiety (BAI, P < 0.001). Multivariate analysis confirmed that breakthrough pain independently contributed to impaired functioning and psychological distress. These data confirm that cancer-related breakthrough pain is a prevalent and heterogeneous phenomenon. The presence of breakthrough pain is a marker of a generally more severe pain syndrome, and is associated with both pain-related functional impairment and psychological distress. The findings suggest the need for further studies of breakthrough pain and more effective therapeutic strategies.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:status |
MEDLINE
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| pubmed:month |
May
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| pubmed:issn |
0304-3959
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
81
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
129-34
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| pubmed:dateRevised |
2004-11-17
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| pubmed:meshHeading |
pubmed-meshheading:10353500-Adult,
pubmed-meshheading:10353500-Aged,
pubmed-meshheading:10353500-Anxiety,
pubmed-meshheading:10353500-Cross-Sectional Studies,
pubmed-meshheading:10353500-Depression,
pubmed-meshheading:10353500-Disability Evaluation,
pubmed-meshheading:10353500-Female,
pubmed-meshheading:10353500-Health Surveys,
pubmed-meshheading:10353500-Humans,
pubmed-meshheading:10353500-Male,
pubmed-meshheading:10353500-Middle Aged,
pubmed-meshheading:10353500-Multivariate Analysis,
pubmed-meshheading:10353500-Neoplasms,
pubmed-meshheading:10353500-Pain,
pubmed-meshheading:10353500-Pain Measurement
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| pubmed:year |
1999
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| pubmed:articleTitle |
Breakthrough pain: characteristics and impact in patients with cancer pain.
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| pubmed:affiliation |
Department of Pain Medicine and Palliative Care, Beth Israel Medical Center, New York, NY 10003, USA.
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| pubmed:publicationType |
Journal Article
|