Linked Life Data

10352924

Source:http://linkedlifedata.com/resource/pubmed/id/10352924

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1999-7-15
pubmed:abstractText
Available studies suggest there is a strong familial component to PCOS regardless of the diagnostic criteria used to ascertain probands and to assign affected status in kindreds. Investigation of all kindred members using the same systematic screen for metabolic and reproductive abnormalities strengthens the validity of conclusions. There is no substitute for direct biometric or biochemical proof of the phenotype. Initial studies by the author and his colleagues suggest that hyperandrogenemia in sisters is a valid phenotype characteristic. Further study is necessary to establish other phenotypes in the families. Large family clusterings of PCOS offer the best opportunity for identifying unique strains of PCOS. These families may represent a homogeneous etiology of the syndrome despite significant phenotypic heterogeneity within a given pedigree. Linkage analysis should be performed between polymorphic markers spaced at regular genetic intervals, and these familial traits may identify critical regions for further investigation.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0889-8529
pubmed:author
pubmed:issnType
Print
pubmed:volume
28
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
379-96
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1999
pubmed:articleTitle
Polycystic ovary syndrome. Phenotype to genotype.
pubmed:affiliation
Department of Obstetrics and Gynecology, Pennsylvania State University College of Medicine, Hershey, USA. rsl1@psu.edu
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Review