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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
22
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pubmed:dateCreated |
1999-6-3
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pubmed:abstractText |
Acute fatty liver of pregnancy and the HELLP syndrome (hemolysis, elevated liver-enzyme levels, and a low platelet count) are serious hepatic disorders that may occur during pregnancy in women whose fetuses are later found to have a deficiency of long-chain 3-hydroxyacyl-coenzyme A (CoA) dehydrogenase. This enzyme resides in the mitochondrial trifunctional protein, which also contains the active site of long-chain 2,3-enoyl-CoA hydratase and long-chain 3-ketoacyl-CoA thiolase. We undertook this study to determine the relation between mutations in the trifunctional protein in infants with defects in fatty-acid oxidation and acute liver disease during pregnancy in their mothers.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0028-4793
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
3
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pubmed:volume |
340
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1723-31
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:10352164-3-Hydroxyacyl CoA Dehydrogenases,
pubmed-meshheading:10352164-Acute Disease,
pubmed-meshheading:10352164-DNA Mutational Analysis,
pubmed-meshheading:10352164-Fatty Acids,
pubmed-meshheading:10352164-Fatty Liver,
pubmed-meshheading:10352164-Female,
pubmed-meshheading:10352164-Fetal Diseases,
pubmed-meshheading:10352164-Genotype,
pubmed-meshheading:10352164-HELLP Syndrome,
pubmed-meshheading:10352164-Humans,
pubmed-meshheading:10352164-Infant,
pubmed-meshheading:10352164-Infant, Newborn,
pubmed-meshheading:10352164-Lipid Metabolism, Inborn Errors,
pubmed-meshheading:10352164-Mitochondria,
pubmed-meshheading:10352164-Multienzyme Complexes,
pubmed-meshheading:10352164-Mutation,
pubmed-meshheading:10352164-Oxidation-Reduction,
pubmed-meshheading:10352164-Pregnancy,
pubmed-meshheading:10352164-Pregnancy Complications
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pubmed:year |
1999
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pubmed:articleTitle |
A fetal fatty-acid oxidation disorder as a cause of liver disease in pregnant women.
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pubmed:affiliation |
Department of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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