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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
1999-6-14
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pubmed:abstractText |
Findings from previous multicenter clinical trials have suggested that tirilazad mesylate, a synthetic nonhormonal 21-aminosteroid, might be effective in preventing delayed cerebral ischemia following subarachnoid hemorrhage (SAH). This beneficial effect, however, was greater in males than females, possibly because of gender-related pharmacokinetic differences. The authors sought to assess the effects of administering a larger dose of tirilazad in women with SAH.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0022-3085
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
90
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1011-7
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:10350245-Dose-Response Relationship, Drug,
pubmed-meshheading:10350245-Double-Blind Method,
pubmed-meshheading:10350245-Female,
pubmed-meshheading:10350245-Humans,
pubmed-meshheading:10350245-Incidence,
pubmed-meshheading:10350245-International Cooperation,
pubmed-meshheading:10350245-Intracranial Aneurysm,
pubmed-meshheading:10350245-Ischemic Attack, Transient,
pubmed-meshheading:10350245-Middle Aged,
pubmed-meshheading:10350245-Nervous System,
pubmed-meshheading:10350245-Neuroprotective Agents,
pubmed-meshheading:10350245-Pharmaceutical Vehicles,
pubmed-meshheading:10350245-Pregnatrienes,
pubmed-meshheading:10350245-Prospective Studies,
pubmed-meshheading:10350245-Subarachnoid Hemorrhage,
pubmed-meshheading:10350245-Time Factors,
pubmed-meshheading:10350245-Treatment Outcome
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pubmed:year |
1999
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pubmed:articleTitle |
Double-blind, randomized, vehicle-controlled study of high-dose tirilazad mesylate in women with aneurysmal subarachnoid hemorrhage. Part I. A cooperative study in Europe, Australia, New Zealand, and South Africa.
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pubmed:affiliation |
Department of Neurological Surgery and Virginia Neurological Institute, University of Virginia, Charlottesville 22908, USA.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't,
Multicenter Study
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