Source:http://linkedlifedata.com/resource/pubmed/id/10348528
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
1999-7-6
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pubmed:abstractText |
The benefit of primary angioplasty in patients with acute myocardial infarction (AMI) and contraindications for thrombolysis compared to a conservative regimen is still unclear. Out of 5,869 patients with AMI registered by the MITRA trial, 337 (5.7%) patients had at least one strong contraindication for thrombolytic therapy. Out of these 337 patients 46 (13.6%) were treated with primary angioplasty and 276 (86.4%) were treated conservatively. Patients treated conservatively were older (70 years vs. 60 years; P=0.001), had a higher rate of a history with chronic heart failure (14.8% vs. 4.4%; P=0.053), a higher heart rate at admission (86 beats/min vs. 74 beats/min; P=0.001), and a higher prevalence of diabetes mellitus (27.1% vs. 12.8%; P=0.056). Patients treated with primary angioplasty received more often aspirin (91.3% vs. 74.6%; P=0.012), beta-blockers (60.9% vs. 46.1%; P = 0.062), angiotensin converting enzyme (ACE) inhibitors (71.7% vs. 44%; P=0.001), and the so-called optimal adjunctive medication (54.4% vs. 32.3%; P=0.004). Hospital mortality was significantly lower in patients who received primary angioplasty (univariate: 2.2% vs. 24.7%; P=0.001; multivariate: OR=0.46; P=0.0230). In patients with AMI and contraindications for thrombolytic therapy, primary angioplasty was associated with a significantly lower mortality compared to conservative treatment. Therefore, hospitals without the facilities to perform primary angioplasty should try to refer such patients to centers with the facilities for such a service, if this is possible in an acceptable time.
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pubmed:commentsCorrections | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1522-1946
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pubmed:author |
pubmed-author:BergGG,
pubmed-author:GieselerUU,
pubmed-author:GottwikMM,
pubmed-author:HauptmannK EKE,
pubmed-author:JakobMM,
pubmed-author:KunzTT,
pubmed-author:MeyerJJ,
pubmed-author:SchieleRR,
pubmed-author:SchusterSS,
pubmed-author:SeidlKK,
pubmed-author:SengesJJ,
pubmed-author:VoigtländerTT,
pubmed-author:ZahnRR
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pubmed:issnType |
Print
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pubmed:volume |
46
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
127-33
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:10348528-Aged,
pubmed-meshheading:10348528-Angioplasty, Balloon, Coronary,
pubmed-meshheading:10348528-Clinical Trials as Topic,
pubmed-meshheading:10348528-Female,
pubmed-meshheading:10348528-Germany,
pubmed-meshheading:10348528-Humans,
pubmed-meshheading:10348528-Male,
pubmed-meshheading:10348528-Middle Aged,
pubmed-meshheading:10348528-Multicenter Studies as Topic,
pubmed-meshheading:10348528-Myocardial Infarction,
pubmed-meshheading:10348528-Survival Analysis,
pubmed-meshheading:10348528-Thrombolytic Therapy,
pubmed-meshheading:10348528-Treatment Outcome
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pubmed:year |
1999
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pubmed:articleTitle |
Comparison of primary angioplasty with conservative therapy in patients with acute myocardial infarction and contraindications for thrombolytic therapy. Maximal Individual Therapy in Acute Myocardial Infarction (MITRA) Study Group.
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pubmed:affiliation |
Department of Cardiology, Herzzentrum Ludwigshafen, Germany.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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