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rdf:type |
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lifeskim:mentions |
umls-concept:C0017262,
umls-concept:C0038435,
umls-concept:C0086418,
umls-concept:C0185117,
umls-concept:C0334227,
umls-concept:C0376358,
umls-concept:C0376571,
umls-concept:C0598034,
umls-concept:C0871261,
umls-concept:C1333336,
umls-concept:C1419240,
umls-concept:C1515926,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C1707511,
umls-concept:C2911684,
umls-concept:C2911692
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pubmed:issue |
1
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pubmed:dateCreated |
1999-6-9
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pubmed:abstractText |
BRCA1 and BRCA2 participate in cell cycle progression, apoptosis, and DNA repair pathways. The latter role may be mediated by interaction with DNA recombinase Rad51. The purpose of this study was to evaluate the effects of genotoxic and other cytotoxic agents on expression of DNA damage-response genes (BRCA1, BRCA2, p300, and Rad51) in human prostate cancer cells.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/BRCA2 Protein,
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Neoplasm,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Mutagens,
http://linkedlifedata.com/resource/pubmed/chemical/Neoplasm Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/RAD51 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Rad51 Recombinase,
http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0270-4137
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
40
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
37-49
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:10344722-BRCA2 Protein,
pubmed-meshheading:10344722-Cell Survival,
pubmed-meshheading:10344722-DNA, Neoplasm,
pubmed-meshheading:10344722-DNA Damage,
pubmed-meshheading:10344722-DNA-Binding Proteins,
pubmed-meshheading:10344722-Down-Regulation,
pubmed-meshheading:10344722-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:10344722-Genes, BRCA1,
pubmed-meshheading:10344722-Humans,
pubmed-meshheading:10344722-Male,
pubmed-meshheading:10344722-Mutagens,
pubmed-meshheading:10344722-Neoplasm Proteins,
pubmed-meshheading:10344722-Nuclear Proteins,
pubmed-meshheading:10344722-Prostatic Neoplasms,
pubmed-meshheading:10344722-RNA, Messenger,
pubmed-meshheading:10344722-Rad51 Recombinase,
pubmed-meshheading:10344722-Trans-Activators,
pubmed-meshheading:10344722-Transcription Factors
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pubmed:year |
1999
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pubmed:articleTitle |
Coordinate alterations in the expression of BRCA1, BRCA2, p300, and Rad51 in response to genotoxic and other stresses in human prostate cancer cells.
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pubmed:affiliation |
Department of Radiation Oncology, Long Island Jewish Medical Center, Long Island Campus for the Albert Einstein College of Medicine, New Hyde Park, New York 11040, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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