Linked Life Data

10344289

Source:http://linkedlifedata.com/resource/pubmed/id/10344289

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4-5
pubmed:dateCreated
1999-7-29
pubmed:abstractText
In the last few years it has been shown that anaplastic oligodendrogliomas, in contrast to anaplastic astrocytomas, are responsive to a three drug regimen chemotherapy. The histologic criteria for the discrimination between oligodendrogliomas and astrocytomas are subject to substantial interobserver variability, particularly in anaplastic and mixed gliomas. In the present study a two-dimensional electrophoresis technique (2-DE) has been applied to glioma samples in an attempt to discriminate the glioma subtypes. It was found that the presence of glial fibrillary acidic protein (GFAP) fragments distinguishes oligodendroglioma from astrocytoma. One-dimensional (1-DE) immunoblots were compared with immunohistologically stained tissue sections in which various GFAP-positive cell types were seen. It is concluded that 2-DE and 1-DE GFAP immunoblotting provide accurate information for the reliable discrimination of anaplastic astrocytomas and oligodendrogliomas.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0173-0835
pubmed:author
pubmed:issnType
Print
pubmed:volume
20
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1087-91
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:articleTitle
Glial fibrillary acidic protein and its fragments discriminate astrocytoma from oligodendroglioma.
pubmed:affiliation
Dept. of Neuro-Oncology, Daniel den Hoed Cancer Center, University Hospital Rotterdam-Dijkzigt, Rotterdam, The Netherlands. luidertm@wxs.nl
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't