| pubmed-article:10342283 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10342283 | lifeskim:mentions | umls-concept:C0001792 | lld:lifeskim |
| pubmed-article:10342283 | lifeskim:mentions | umls-concept:C1280551 | lld:lifeskim |
| pubmed-article:10342283 | lifeskim:mentions | umls-concept:C0006104 | lld:lifeskim |
| pubmed-article:10342283 | lifeskim:mentions | umls-concept:C0475264 | lld:lifeskim |
| pubmed-article:10342283 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:10342283 | pubmed:dateCreated | 1999-7-27 | lld:pubmed |
| pubmed-article:10342283 | pubmed:abstractText | Localization of metallothionein (MT) -I & -II and MT-III and its significance in the brain aging in dogs were examined using immunohistological and molecular pathological techniques. MT-I & -II immunohistochemistry showed positive staining in the hypertrophic astrocytes throughout the aged dog brains; these MT-I & -II immunoreactive astrocytes were predominant in the cerebral cortex and around the blood vessels in the brain. These findings dominated in the brain regions with severe age-related morphological changes. In situ hybridization using MT-I mRNA riboprobes also demonstrated signals for MT-I mRNA in these hypertrophic astrocytes. Immunohistochemistry using a guinea pig antiserum against a synthetic polypeptide of canine MT-III demonstrated positive MT-III immunoreactivity predominantly in neurons in the Zn-rich regions such as hippocampus and parahippocampus. The findings were supported by in situ hybridization using MT-III mRNA riboprobes. Both MT-III immunoreactivity and signals for MT-III mRNA were demonstrated in neurons in the brain regardless of the intensity of the age-related changes. These results suggest, first, MT-I & -II may be induced in relation to the progress of the age-related morphological changes in the brain, playing an important role in the protection of the brain tissue from the toxic insults responsible for the brain aging, and second, MT-III may play a role in maintenance of Zn-related essential functions of the brain. | lld:pubmed |
| pubmed-article:10342283 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10342283 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10342283 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10342283 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10342283 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10342283 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10342283 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10342283 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10342283 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:10342283 | pubmed:issn | 0916-7250 | lld:pubmed |
| pubmed-article:10342283 | pubmed:author | pubmed-author:MoritzMM | lld:pubmed |
| pubmed-article:10342283 | pubmed:author | pubmed-author:ShimadaAA | lld:pubmed |
| pubmed-article:10342283 | pubmed:author | pubmed-author:KojimaSS | lld:pubmed |
| pubmed-article:10342283 | pubmed:author | pubmed-author:YamanaKK | lld:pubmed |
| pubmed-article:10342283 | pubmed:author | pubmed-author:UmemuraTT | lld:pubmed |
| pubmed-article:10342283 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10342283 | pubmed:volume | 61 | lld:pubmed |
| pubmed-article:10342283 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10342283 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10342283 | pubmed:pagination | 343-9 | lld:pubmed |
| pubmed-article:10342283 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:10342283 | pubmed:meshHeading | pubmed-meshheading:10342283... | lld:pubmed |
| pubmed-article:10342283 | pubmed:meshHeading | pubmed-meshheading:10342283... | lld:pubmed |
| pubmed-article:10342283 | pubmed:meshHeading | pubmed-meshheading:10342283... | lld:pubmed |
| pubmed-article:10342283 | pubmed:meshHeading | pubmed-meshheading:10342283... | lld:pubmed |
| pubmed-article:10342283 | pubmed:meshHeading | pubmed-meshheading:10342283... | lld:pubmed |
| pubmed-article:10342283 | pubmed:meshHeading | pubmed-meshheading:10342283... | lld:pubmed |
| pubmed-article:10342283 | pubmed:meshHeading | pubmed-meshheading:10342283... | lld:pubmed |
| pubmed-article:10342283 | pubmed:meshHeading | pubmed-meshheading:10342283... | lld:pubmed |
| pubmed-article:10342283 | pubmed:meshHeading | pubmed-meshheading:10342283... | lld:pubmed |
| pubmed-article:10342283 | pubmed:meshHeading | pubmed-meshheading:10342283... | lld:pubmed |
| pubmed-article:10342283 | pubmed:meshHeading | pubmed-meshheading:10342283... | lld:pubmed |
| pubmed-article:10342283 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10342283 | pubmed:articleTitle | Localization of metallothioneins-I & -II and -III in the brain of aged dog. | lld:pubmed |
| pubmed-article:10342283 | pubmed:affiliation | Department of Veterinary Pathology, Tottori University, Japan. | lld:pubmed |
| pubmed-article:10342283 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10342283 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10342283 | lld:pubmed |
