rdf:type |
|
lifeskim:mentions |
umls-concept:C0011155,
umls-concept:C0021665,
umls-concept:C0030705,
umls-concept:C0178602,
umls-concept:C0178665,
umls-concept:C0205251,
umls-concept:C0229671,
umls-concept:C0750502,
umls-concept:C0868945,
umls-concept:C1837352,
umls-concept:C1881197,
umls-concept:C1882115
|
pubmed:issue |
1
|
pubmed:dateCreated |
1999-6-9
|
pubmed:abstractText |
Many GH deficient (GHD) patients have impaired glucose tolerance and GH substitution in these patients has caused deleterious effects on glucose tolerance with hyperinsulinaemia. This further impairment of glucose tolerance might be due to an unphysiologically high dose of GH. Whether such a deterioration can be avoided by an optimal GH replacement dose is not known. In most previous studies, the GH dose was calculated according to body weight or body surface area and not adjusted according to the serum IGF-I response.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Jan
|
pubmed:issn |
0300-0664
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
50
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
45-55
|
pubmed:dateRevised |
2011-11-17
|
pubmed:meshHeading |
pubmed-meshheading:10341855-Adult,
pubmed-meshheading:10341855-Blood Glucose,
pubmed-meshheading:10341855-Body Composition,
pubmed-meshheading:10341855-Body Mass Index,
pubmed-meshheading:10341855-Drug Administration Schedule,
pubmed-meshheading:10341855-Female,
pubmed-meshheading:10341855-Glucose Tolerance Test,
pubmed-meshheading:10341855-Growth Hormone,
pubmed-meshheading:10341855-Humans,
pubmed-meshheading:10341855-Insulin,
pubmed-meshheading:10341855-Insulin-Like Growth Factor Binding Protein 1,
pubmed-meshheading:10341855-Insulin-Like Growth Factor I,
pubmed-meshheading:10341855-Male,
pubmed-meshheading:10341855-Quality of Life
|
pubmed:year |
1999
|
pubmed:articleTitle |
A low individualized GH dose in young patients with childhood onset GH deficiency normalized serum IGF-I without significant deterioration in glucose tolerance.
|
pubmed:affiliation |
Department of Internal Medicine, University Hospital, Lund, Sweden.
|
pubmed:publicationType |
Journal Article,
Clinical Trial,
Research Support, Non-U.S. Gov't
|