| pubmed-article:10341316 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10341316 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:10341316 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:10341316 | lifeskim:mentions | umls-concept:C0020967 | lld:lifeskim |
| pubmed-article:10341316 | lifeskim:mentions | umls-concept:C0043481 | lld:lifeskim |
| pubmed-article:10341316 | lifeskim:mentions | umls-concept:C1948023 | lld:lifeskim |
| pubmed-article:10341316 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:10341316 | lifeskim:mentions | umls-concept:C1704666 | lld:lifeskim |
| pubmed-article:10341316 | lifeskim:mentions | umls-concept:C1517892 | lld:lifeskim |
| pubmed-article:10341316 | lifeskim:mentions | umls-concept:C0208973 | lld:lifeskim |
| pubmed-article:10341316 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:10341316 | pubmed:dateCreated | 1999-6-10 | lld:pubmed |
| pubmed-article:10341316 | pubmed:abstractText | Effects of peptidoglycan linked with zinc (PGM-Zn) were investigated on plaque-forming cell (PFC) generation to sheep red blood cell (SRBC) and SRBC-unrelated antibody production in primary and secondary immune response in mice depleted in vivo of CD4+ and/or CD8+ T lymphocytes. PGM-Zn in nondepleted mice stimulated the PFC generation and IgM or IgG and IgG1 production in primary and secondary reaction. Single depletion of CD4 or CD8+ T cells did not change this ability. The effects of PGM-Zn after CD8+ depletion were even greater than those in nondepleted mice. Depletion of both T cell subsets, however, completely abrogated immunostimulatory effects of PGM on PFC generation (primary and secondary response), as well as on primary SRBC-unrelated antibody production, leaving only the increase of IgG in secondary response unchanged. Immunostimulatory effects and isotype switching to IgG1 and IgG2a correlated with the changes in splenic CD4+, CD8+, CD5+ cells, pointing to the regulatory role of these cells and/or their cytokines in PGM-Zn-induced immunostimulation. Altogether the data suggest that PGM-Zn may potentiate the costimulatory signals coming from activated T cells and act on B cells without the T cell help. | lld:pubmed |
| pubmed-article:10341316 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10341316 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10341316 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10341316 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10341316 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10341316 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10341316 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10341316 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10341316 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10341316 | pubmed:month | May | lld:pubmed |
| pubmed-article:10341316 | pubmed:issn | 1018-2438 | lld:pubmed |
| pubmed-article:10341316 | pubmed:author | pubmed-author:RukavinaDD | lld:pubmed |
| pubmed-article:10341316 | pubmed:author | pubmed-author:Radosevi?-Sta... | lld:pubmed |
| pubmed-article:10341316 | pubmed:author | pubmed-author:CukMM | lld:pubmed |
| pubmed-article:10341316 | pubmed:author | pubmed-author:Petkovi?MM | lld:pubmed |
| pubmed-article:10341316 | pubmed:author | pubmed-author:TrobonjacaZZ | lld:pubmed |
| pubmed-article:10341316 | pubmed:author | pubmed-author:Ravli?-GulanJ... | lld:pubmed |
| pubmed-article:10341316 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10341316 | pubmed:volume | 119 | lld:pubmed |
| pubmed-article:10341316 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10341316 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10341316 | pubmed:pagination | 13-22 | lld:pubmed |
| pubmed-article:10341316 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:10341316 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10341316 | pubmed:articleTitle | On the role of T lymphocytes in stimulation of humoral immunity induced by peptidoglycan-monomer linked with zinc. | lld:pubmed |
| pubmed-article:10341316 | pubmed:affiliation | Department of Physiology and Immunology, Medical Faculty, University of Rijeka, Croatia. | lld:pubmed |
| pubmed-article:10341316 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10341316 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10341316 | lld:pubmed |
