Source:http://linkedlifedata.com/resource/pubmed/id/10341316
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
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| pubmed:dateCreated |
1999-6-10
|
| pubmed:abstractText |
Effects of peptidoglycan linked with zinc (PGM-Zn) were investigated on plaque-forming cell (PFC) generation to sheep red blood cell (SRBC) and SRBC-unrelated antibody production in primary and secondary immune response in mice depleted in vivo of CD4+ and/or CD8+ T lymphocytes. PGM-Zn in nondepleted mice stimulated the PFC generation and IgM or IgG and IgG1 production in primary and secondary reaction. Single depletion of CD4 or CD8+ T cells did not change this ability. The effects of PGM-Zn after CD8+ depletion were even greater than those in nondepleted mice. Depletion of both T cell subsets, however, completely abrogated immunostimulatory effects of PGM on PFC generation (primary and secondary response), as well as on primary SRBC-unrelated antibody production, leaving only the increase of IgG in secondary response unchanged. Immunostimulatory effects and isotype switching to IgG1 and IgG2a correlated with the changes in splenic CD4+, CD8+, CD5+ cells, pointing to the regulatory role of these cells and/or their cytokines in PGM-Zn-induced immunostimulation. Altogether the data suggest that PGM-Zn may potentiate the costimulatory signals coming from activated T cells and act on B cells without the T cell help.
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| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Acetylmuramyl-Alanyl-Isoglutamine,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD5,
http://linkedlifedata.com/resource/pubmed/chemical/Peptidoglycan,
http://linkedlifedata.com/resource/pubmed/chemical/Zinc,
http://linkedlifedata.com/resource/pubmed/chemical/peptidoglycan pentapeptide-mDap3
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| pubmed:status |
MEDLINE
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| pubmed:month |
May
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| pubmed:issn |
1018-2438
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
119
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
13-22
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| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:10341316-Acetylmuramyl-Alanyl-Isoglutamine,
pubmed-meshheading:10341316-Animals,
pubmed-meshheading:10341316-Antibody Formation,
pubmed-meshheading:10341316-Antigens, CD5,
pubmed-meshheading:10341316-Bone Marrow Cells,
pubmed-meshheading:10341316-CD4-Positive T-Lymphocytes,
pubmed-meshheading:10341316-CD8-Positive T-Lymphocytes,
pubmed-meshheading:10341316-Erythrocytes,
pubmed-meshheading:10341316-Hemolytic Plaque Technique,
pubmed-meshheading:10341316-Lymphocyte Activation,
pubmed-meshheading:10341316-Lymphocyte Count,
pubmed-meshheading:10341316-Male,
pubmed-meshheading:10341316-Mice,
pubmed-meshheading:10341316-Mice, Inbred BALB C,
pubmed-meshheading:10341316-Peptidoglycan,
pubmed-meshheading:10341316-Sheep,
pubmed-meshheading:10341316-Spleen,
pubmed-meshheading:10341316-T-Lymphocyte Subsets,
pubmed-meshheading:10341316-T-Lymphocytes,
pubmed-meshheading:10341316-Thymus Gland,
pubmed-meshheading:10341316-Zinc
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| pubmed:year |
1999
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| pubmed:articleTitle |
On the role of T lymphocytes in stimulation of humoral immunity induced by peptidoglycan-monomer linked with zinc.
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| pubmed:affiliation |
Department of Physiology and Immunology, Medical Faculty, University of Rijeka, Croatia.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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