Linked Life Data

10340530

Source:http://linkedlifedata.com/resource/pubmed/id/10340530

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1999-7-28
pubmed:abstractText
An opaque screen moving overhead elicits an escape response in the crab Chasmagnathus, which, after a few presentations, habituates for a long period (long-term habituation, LTH). Previous results distinguished two types of LTH: the (context-signal)-LTH yielded by spaced training, determined by an association between context and habituating stimulus, and cycloheximide sensitive: and the (signal)-LTH produced by massed training, context independent, and cycloheximide insensitive. Present experiments were aimed at studying the possible involvement of cholinergic mechanisms in one or both types of LTH, using the muscarinic antagonist, scopolamine (SCP). Results indicate that LTH acquired by spaced training (30 trials separated by 85 s) is blocked in a dose-dependent manner by posttraining SCP. Amnesia is shown with 100 ng SCP/g injected immediately before or after spaced training but not delayed 1-h posttraining. No effect of SCP on LTH acquired by massed training (300 trials separated by 4 s) is detected. Pretraining SCP induces a decrease in the response level at the initial trials of either a spaced or a massed training. It is concluded that the storage of (context-signal)-LTH may be selectively regulated by a muscarinic-cholinergic mechanism. However, the possibility that other cholinergic receptors would be involved in the consolidation of the (signal)-LTH is discussed.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0091-3057
pubmed:author
pubmed:issnType
Print
pubmed:volume
63
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
109-18
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:year
1999
pubmed:articleTitle
Two related forms of long-term habituation in the crab Chasmagnathus are differentially affected by scopolamine.
pubmed:affiliation
Facultad de Ciencias Exactas y Naturales, Depto. Biología, Universidad de Buenos Aires, Argentina.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't