rdf:type |
|
lifeskim:mentions |
umls-concept:C0015259,
umls-concept:C0018801,
umls-concept:C0023977,
umls-concept:C0023981,
umls-concept:C0025859,
umls-concept:C0034656,
umls-concept:C0054836,
umls-concept:C0242606,
umls-concept:C1280500,
umls-concept:C1457887,
umls-concept:C1707455,
umls-concept:C2700378
|
pubmed:issue |
20
|
pubmed:dateCreated |
1999-6-15
|
pubmed:abstractText |
With beta-blocker use becoming more prevalent in treating chronic heart failure (CHF), the choice of drugs raises important theoretical and practical questions. Although the second-generation compound metoprolol is beta1-selective, the third-generation compound carvedilol is beta-nonselective, with ancillary pharmacological properties including alpha-blockade and antioxidant effects. A prospective comparison of these 2 agents can address the issue of optimal adrenergic blockade in selecting agents for therapy in CHF.
|
pubmed:commentsCorrections |
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
AIM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
May
|
pubmed:issn |
1524-4539
|
pubmed:author |
|
pubmed:issnType |
Electronic
|
pubmed:day |
25
|
pubmed:volume |
99
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
2645-51
|
pubmed:dateRevised |
2006-11-15
|
pubmed:meshHeading |
pubmed-meshheading:10338457-Adrenergic beta-Antagonists,
pubmed-meshheading:10338457-Adult,
pubmed-meshheading:10338457-Aged,
pubmed-meshheading:10338457-Carbazoles,
pubmed-meshheading:10338457-Cardiac Output, Low,
pubmed-meshheading:10338457-Chronic Disease,
pubmed-meshheading:10338457-Exercise,
pubmed-meshheading:10338457-Female,
pubmed-meshheading:10338457-Humans,
pubmed-meshheading:10338457-Male,
pubmed-meshheading:10338457-Metoprolol,
pubmed-meshheading:10338457-Middle Aged,
pubmed-meshheading:10338457-Oxidative Stress,
pubmed-meshheading:10338457-Propanolamines,
pubmed-meshheading:10338457-Prospective Studies,
pubmed-meshheading:10338457-Stroke Volume,
pubmed-meshheading:10338457-Thiobarbituric Acid Reactive Substances
|
pubmed:year |
1999
|
pubmed:articleTitle |
Prospective, randomized comparison of effect of long-term treatment with metoprolol or carvedilol on symptoms, exercise, ejection fraction, and oxidative stress in heart failure.
|
pubmed:affiliation |
Cardiovascular Institute, Mount Sinai School of Medicine, New York, NY 10029, USA. marrickvkukin@mssm.edu
|
pubmed:publicationType |
Journal Article,
Clinical Trial,
Comparative Study,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't
|