Linked Life Data

10336055

Source:http://linkedlifedata.com/resource/pubmed/id/10336055

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PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1999-8-2
pubmed:abstractText
The properties of postsynaptic potentials evoked by stimulation of cortical, retinal and GABAergic thalamic afferents were examined in vitro in thalamocortical neurons of the guinea-pig dorsal lateral geniculate nucleus. Brief trains of stimulation (2-10 stimuli) delivered to corticothalamic fibers led to a frequency-dependent increase in excitatory postsynaptic potential amplitude associated with an increase in activation of both N-methyl-D-aspartate and non-N-methyl-D-aspartate glutamate receptors. In addition, repetitive stimulation of corticothalamic fibers also gave rise to a slow excitatory postsynaptic potential that was blocked by local application of the glutamate metabotropic receptor antagonist alpha-methyl-4-carboxyphenylglycine. In contrast, repetitive stimulation of optic tract fibers resulted in monosynaptic excitatory postsynaptic potentials that did not potentiate and were not followed by the generation of a slow excitatory postsynaptic potential. Repetitive activation of the optic radiation also evoked both GABA(A) and GABA(B) receptor-mediated inhibitory postsynaptic potentials. These inhibitory postsynaptic potentials exhibited frequency-dependent depression during repetitive activation. The presence of frequency-dependent facilitation of corticothalamic excitatory postsynaptic potentials and frequency-dependent decrement of inhibitory postsynaptic potentials, as well as the ability of corticothalamic fibers to activate glutamate metabotropic receptors, suggests that sustained activation of corticothalamic afferents in vivo may result in postsynaptic responses in thalamocortical cells that are initially dominated by GABAergic inhibitory postsynaptic potentials followed by prominent monosynaptic excitatory postsynaptic potentials as well as a slow depolarization of the membrane potential.Therefore, the corticothalamic system may inhibit or enhance the excitability and responsiveness of thalamocortical neurons, based both on the spatial and temporal features of thalamocortical interactions.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0306-4522
pubmed:author
pubmed:issnType
Print
pubmed:volume
91
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
7-20
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:10336055-Animals, pubmed-meshheading:10336055-Cerebral Cortex, pubmed-meshheading:10336055-Electric Stimulation, pubmed-meshheading:10336055-Excitatory Postsynaptic Potentials, pubmed-meshheading:10336055-Female, pubmed-meshheading:10336055-GABA Agonists, pubmed-meshheading:10336055-GABA Antagonists, pubmed-meshheading:10336055-Geniculate Bodies, pubmed-meshheading:10336055-Guinea Pigs, pubmed-meshheading:10336055-Male, pubmed-meshheading:10336055-Membrane Potentials, pubmed-meshheading:10336055-Nerve Fibers, pubmed-meshheading:10336055-Neurons, pubmed-meshheading:10336055-Receptors, GABA-A, pubmed-meshheading:10336055-Receptors, GABA-B, pubmed-meshheading:10336055-Receptors, Metabotropic Glutamate, pubmed-meshheading:10336055-Reticular Formation, pubmed-meshheading:10336055-Retina, pubmed-meshheading:10336055-Thalamus, pubmed-meshheading:10336055-gamma-Aminobutyric Acid
pubmed:year
1999
pubmed:articleTitle
Dynamic properties of corticothalamic excitatory postsynaptic potentials and thalamic reticular inhibitory postsynaptic potentials in thalamocortical neurons of the guinea-pig dorsal lateral geniculate nucleus.
pubmed:affiliation
Yale University School of Medicine, Section of Neurobiology, New Haven, CT 06510-8001, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't