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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2-3
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pubmed:dateCreated |
1977-1-25
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pubmed:abstractText |
The synthesis of catecholamines (CA) has been studied in the heart, spleen, submaxillary glands and adrenals of rats exposed to 4 degrees C for 2.5, 24 or 48 h. The synthesis rate has been estimated 30 min after an i.v. injection of 3H tyrosine (TY) by the evaluation of the ratio: 3H-CA specific activity/3H-TY specific activity. In the sub-maxillary glands, cold exposure reduced the noradrenaline (NA) synthesis by 40% at times 24 and 48 h. In the spleen, NA synthesis was multiplied by a factor 1.6 at times 2.5 and 24 h and 2.8 at time 48 h. In the heart, it was increased by a factor 1.3 after 2.5 h, 2.8 after 24 h and 5.5 after 48 h: an important fall in cardiac NA level was observed during the first 24 h of cold exposure indicating that the synthesis capability was unsufficient to compensate the cold-induced NA release. In the adrenals, adrenaline + NA synthesis was not significantly enhanced during the first 24 h of cold exposure and increased by a factor 2.4 at time 48 h. The important increases in CA synthesis which are observed during the 24-48 h interval are likely consecutive to the induction of tyrosine hydroxylase which has been reported in the rat exposed to cold.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0031-6768
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
5
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pubmed:volume |
366
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pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
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pubmed:pagination |
259-64
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:1033528-Adrenal Medulla,
pubmed-meshheading:1033528-Animals,
pubmed-meshheading:1033528-Cold Temperature,
pubmed-meshheading:1033528-Epinephrine,
pubmed-meshheading:1033528-Male,
pubmed-meshheading:1033528-Myocardium,
pubmed-meshheading:1033528-Norepinephrine,
pubmed-meshheading:1033528-Rats,
pubmed-meshheading:1033528-Spleen,
pubmed-meshheading:1033528-Submandibular Gland
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pubmed:year |
1976
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pubmed:articleTitle |
Evolution in vivo of the synthesis rate of catecholamines in various peripheral organs of the rat during cold exposure.
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pubmed:publicationType |
Journal Article
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